1: H2 / Pd/C View Scheme

1: dimethylformamide / 120 °C 2: 1.) MeNH2, 2.) HCl View Scheme

n-ethyl morpholine; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide in tetrahydrofuran 64 h; Ambient temperature;

1: 70 percent / aq. HCl 2: COCl2 4: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 5: dimethylformamide / 120 °C 6: 1.) MeNH2, 2.) HCl View Scheme

1: COCl2 3: 85 percent / H2 / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr 4: dimethylformamide / 120 °C 5: 1.) MeNH2, 2.) HCl View Scheme

1: 1.) carbonyldiimidazole 2: NaBH4 / ethanol / 1 h / -15 - -10 °C 3: 89 percent / TsOH*H2O / 5 h / 60 °C 4: 92 percent / 1 M aq. NaOH / ethanol / 18 h / Ambient temperature 5: (COCl)2, DMF / toluene / 1 h 6: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation 7: aq. AcOH, conc. HCl / 3 h / Ambient temperature 8: 92 percent / KOH / methanol / 3 h / Ambient temperature 9: 86 percent / propan-2-ol / 6 h / 80 °C 10: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h 11: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature View Scheme

1: SOCl2 / CCl4 / 0.5 h / Heating 2: RuCl3*3H2O, NaIO4 / acetonitrile; H2O / 1 h / Ambient temperature 3: 2.) 10percent H2SO4 / 1.) THF, r.t., 2.) 70percent aq. MeOH, reflux, 4 h 4: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h / 2585.7 Torr / Ambient temperature 5: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature View Scheme

1: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h / 2585.7 Torr / Ambient temperature 2: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature View Scheme

1: 86 percent / propan-2-ol / 6 h / 80 °C 2: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h 3: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature View Scheme

1: 2.) 10percent H2SO4 / 1.) THF, r.t., 2.) 70percent aq. MeOH, reflux, 4 h 2: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h / 2585.7 Torr / Ambient temperature 3: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature View Scheme