1: 92 percent / KOH / methanol / 3 h / Ambient temperature
2: 86 percent / propan-2-ol / 6 h / 80 °C
3: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h
4: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature
View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
1: NaBH4 / ethanol / 1 h / -15 - -10 °C
2: 89 percent / TsOH*H2O / 5 h / 60 °C
3: 92 percent / 1 M aq. NaOH / ethanol / 18 h / Ambient temperature
4: (COCl)2, DMF / toluene / 1 h
5: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation
6: aq. AcOH, conc. HCl / 3 h / Ambient temperature
7: 92 percent / KOH / methanol / 3 h / Ambient temperature
8: 86 percent / propan-2-ol / 6 h / 80 °C
9: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h
10: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature
View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
1: (COCl)2, DMF / toluene / 1 h
2: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation
3: aq. AcOH, conc. HCl / 3 h / Ambient temperature
4: 92 percent / KOH / methanol / 3 h / Ambient temperature
5: 86 percent / propan-2-ol / 6 h / 80 °C
6: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h
7: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature
View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
1: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation
2: aq. AcOH, conc. HCl / 3 h / Ambient temperature
3: 92 percent / KOH / methanol / 3 h / Ambient temperature
4: 86 percent / propan-2-ol / 6 h / 80 °C
5: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h
6: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature
View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
1: 92 percent / 1 M aq. NaOH / ethanol / 18 h / Ambient temperature
2: (COCl)2, DMF / toluene / 1 h
3: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation
4: aq. AcOH, conc. HCl / 3 h / Ambient temperature
5: 92 percent / KOH / methanol / 3 h / Ambient temperature
6: 86 percent / propan-2-ol / 6 h / 80 °C
7: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h
8: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature
View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
1: 89 percent / TsOH*H2O / 5 h / 60 °C
2: 92 percent / 1 M aq. NaOH / ethanol / 18 h / Ambient temperature
3: (COCl)2, DMF / toluene / 1 h
4: CBrCl3, 2-mercaptopyridine N-oxide sodium salt, 4-(dimethylamino)pyridine / 1 h / 80 °C / Irradiation
5: aq. AcOH, conc. HCl / 3 h / Ambient temperature
6: 92 percent / KOH / methanol / 3 h / Ambient temperature
7: 86 percent / propan-2-ol / 6 h / 80 °C
8: 100 percent / H2 / 10percent Pd/C / ethanol / 24 h
9: 48 percent / 1-hydroxybenzotriazole hydrate, dicyclohexylcarbodiimide, N-ethylmorpholine / tetrahydrofuran / 64 h / Ambient temperature
View Scheme
参考文献
Parkes, Kevin E. B.; Bushnell, David J.; Crackett, Peter H.; Dunsdon, Stephen J.; Freeman, Andrew C.; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3656 - 3664
