2-氨基-5-氯噻唑-4-羧酸乙酯合成路线 （共 5 条）
反应条件
N-chloro-succinimide in acetonitrile 3 h; Heating;
参考文献
South, Michael S.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 1003 - 1011
反应条件
1: With N-iodo-succinimide in acetonitrile T=20 - 90°C; Reflux; 2: With sodium hydroxide in water
参考文献
ACTELION PHARMACEUTICALS LTD; CAROFF, Eva; HILPERT, Kurt; HUBLER, Francis; LEHMANN, David; MEYER, Emmanuel; RENNEBERG, Dorte
Patent: WO2010/122504 A1, 2010 ;
Location in patent: Page/Page column 53-54 ;
WO 2010/122504 A1
反应条件
1: With tert.-butylnitrite in acetonitrile T=60 - 80°C; 2 h; 2: With hydrogenchloride in dichloromethane; acetonitrile
参考文献
Hodgetts, Kevin J.; Kershaw, Mark T.
Organic Letters, 2002 , vol. 4, # 8 p. 1363 - 1365
反应条件
tert.-butylnitrite; copper dichloride in acetonitrile 1 h;
参考文献
South, Michael S.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 1003 - 1011
反应条件
tert.-butylnitrite in DMF (N,N-dimethyl-formamide)
T=65°C; 0.166667 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/26177 A1, 2005 ;
Location in patent: Page/Page column 33; 78-79 ;
WO 2005/026177 A1
