2,2-二甲基-6-硝基-4-(1-氧代吡啶-1-鎓-2-基)-3H-1,4-苯并恶嗪合成路线 （共 3 条）
反应条件
sodium hydride 1.) DMF, 30 min, 2.) DMF, RT, 2 h; Yield given. Multistep reaction;
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US5420126 A1, 1995 ;
US 5420126 A
反应条件
1: 70 percent / potassium carbonate / dimethylformamide / 50 °C 2: 1.) BH3, 2.) methanol, 3.) conc. HCl 3: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h View Scheme
参考文献
Matsumoto, Yuzo; Tsuzuki, Ryuji; Matsuhisa, Akira; Takayama, Kazuhisa; Yoden, Toru; Uchida, Wataru; Asano, Masaharu; Fujita, Shigeo; Yanagisawa, Isao; Fujikura, Takashi
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 103 - 114
反应条件
1: 82 percent / Et3N / tetrahydrofuran 2: 70 percent / potassium carbonate / dimethylformamide / 50 °C 3: 1.) BH3, 2.) methanol, 3.) conc. HCl 4: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 2 h View Scheme
参考文献
Matsumoto, Yuzo; Tsuzuki, Ryuji; Matsuhisa, Akira; Takayama, Kazuhisa; Yoden, Toru; Uchida, Wataru; Asano, Masaharu; Fujita, Shigeo; Yanagisawa, Isao; Fujikura, Takashi
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 103 - 114
