7-氯-2,5-二甲基吡唑并[1,5-a]嘧啶合成路线 （共 2 条）
反应条件
trichlorophosphate in acetonitrile T=90°C; 16 h;
参考文献
SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC
Patent: WO2005/63756 A1, 2005 ;
Location in patent: Page/Page column 37-38 ;
WO 2005/063756 A1
反应条件
1: With N,N-diethylaniline in 1,4-dioxane T=22°C; 0.0833333 h; 2: With trichlorophosphate in 1,4-dioxane T=22 - 85°C; 2.58333 h; 3: With dipotassium hydrogenphosphate; water in 1,4-dioxane T=0 - 22°C; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/36579 A1, 2008 ;
Location in patent: Page/Page column 21-22 ;
WO 2008/036579 A1
