1: methylamine / water; isopropyl alcohol / 1 h / 75 °C 2: isopropyl alcohol / 1.5 h / 5 - 65 °C / Large scale reaction 3: sodium hydrogencarbonate / dichloromethane; water / 0.5 h 4: triethylamine / toluene / 0.5 h / -5 - 5 °C View Scheme

1: methylamine / water; isopropyl alcohol / 1 h / 75 °C 2: isopropyl alcohol / 1.5 h / 5 - 65 °C / Large scale reaction 3: sodium hydrogencarbonate / dichloromethane; water / 0.5 h View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: phosphorous pentoxide / 1.25 h / 35 &deg;C / Inert atmosphere; Large scale reaction<br />2: tetrabutylammomium bromide; potassium iodide / N,N-dimethyl-formamide / 14 h / 85 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: sodium hydrogencarbonate / water; toluene / 0.5 h / Large scale reaction<br />1.2: 1.5 h / Reflux<br />2.1: phosphorous pentoxide / 1.25 h / 35 &deg;C / Inert atmosphere; Large scale reaction<br />3.1: tetrabutylammomium bromide; potassium iodide / N,N-dimethyl-formamide / 14 h / 85 &deg;C<br /> <br /> &nbsp;