(2R,3S)-3-苯基异丝胺酸合成路线 （共 18 条）
反应条件
1: 69 percent / 2.5 molpercent (DHQ)2-PHAL, 2.0 molpercent K2OsO2(OH)4 / 2-methyl-propan-2-ol; H2O / Ambient temperature 2: 77 percent / phenol, 33percent HBr / acetic acid / 12 h / 75 °C View Scheme
参考文献
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), , vol. 50, # 8 p. 649 - 651
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
1: K2OsO2; (DHQ)2PHAL 2: aq. HCl / 2 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2693 - 2697
反应条件
hydrogenchloride Heating;
参考文献
Angewandte Chemie, , vol. 108, # 4 p. 449 - 452
反应条件
1: HCl 2: NaHCO3 / ethyl acetate View Scheme
参考文献
Howarth, Joshua; Kenny, Padraic; McDonnell, Susan; O'Connor, Aine
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2693 - 2697
反应条件
1: 41 percent / toluene / 8 h / Heating 2: 86 percent / NaOH / methanol; H2O / 20 °C View Scheme
参考文献
Daniewski; Gumulka; Kopczacki; Masnyk
Polish Journal of Chemistry, 2001 , vol. 75, # 9 p. 1287 - 1296
反应条件
sodium hydrogencarbonate T=4°C; 6 h;
参考文献
Deng, Li; Jacobsen, Eric N.
Journal of Organic Chemistry, 1992 , vol. 57, # 15 p. 4320 - 4323
反应条件
1: HCl 2: NaHCO3 / ethyl acetate 3: aq. PTSA / 80 °C 4: LiOH / H2O / 0.33 h / 0 °C View Scheme
参考文献
Howarth, Joshua; Kenny, Padraic; McDonnell, Susan; O'Connor, Aine
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 16 p. 2693 - 2697
