1: 95 percent / 1 h / 110 °C 2: tetrahydrofuran / 1 h / -70 °C 3: 1.) trifluoroacetic anhydride, 2.) 15percent aq. NaOH / 1.) CH2Cl2, r.t., 4 h, 2.) MeOH, r.t., 6 h 4: HCl / methanol / Ambient temperature View Scheme

1: 1.) trifluoroacetic anhydride, 2.) 15percent aq. NaOH / 1.) CH2Cl2, r.t., 4 h, 2.) MeOH, r.t., 6 h 2: HCl / methanol / Ambient temperature View Scheme

1: 95 percent / molecular sieves 4 Angstroem / diethyl ether / 0.33 h / Ambient temperature 2: 95 percent / 1 h / 110 °C 3: tetrahydrofuran / 1 h / -70 °C 4: 1.) trifluoroacetic anhydride, 2.) 15percent aq. NaOH / 1.) CH2Cl2, r.t., 4 h, 2.) MeOH, r.t., 6 h 5: HCl / methanol / Ambient temperature View Scheme

1: 95 percent / molecular sieves 4 Angstroem / diethyl ether / 0.33 h / Ambient temperature 2: 1.) CuBr, Me2S, LiBr / 2.) THF, -70 deg C, 30 min View Scheme

hydrogenchloride in methanol Ambient temperature; Title compound not separated from byproducts;

1: 80 percent / LiBr / tetrahydrofuran 2: LiAlH4 / diethyl ether / 12 h / Heating 3: 75 percent / HCl / methanol 4: 1) TFAA, 2) aq. NaOH / 1) CH2Cl2, 15 min, 2) CH3OH, 12 h View Scheme

1: LiAlH4 / diethyl ether / 12 h / Heating 2: 75 percent / HCl / methanol 3: 1) TFAA, 2) aq. NaOH / 1) CH2Cl2, 15 min, 2) CH3OH, 12 h View Scheme

sodium hydroxide; trifluoroacetic anhydride 1) CH2Cl2, 15 min, 2) CH3OH, 12 h; Yield given. Multistep reaction;

dimethylsulfide; copper(I) bromide; lithium bromide 2.) THF, -70 deg C, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;