反应条件
1.1: ethanol; water / 0.83 h / 50 °C
1.2: Cooling with ice
2.1: ethanol; sodium tetrahydroborate / 72 h / 20 °C
3.1: hydrogenchloride / water / 100 °C
4.1: tetrahydrofuran / Reflux
5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran
6.1: toluene-4-sulfonic acid / toluene / 4 h / 110 °C
6.2: pH 7
View Scheme
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
