1-(4-溴苯肼)-2-苯乙炔合成路线 （共 49 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetra-(n-butyl)ammonium iodide; diethylamine in acetonitrile
T=20°C; Sonogashira coupling; 2 h; Inert atmosphere;
参考文献
Fabrizi, Giancarlo; Goggiamani, Antonella; Sferrazza, Alessio; Cacchi, Sandro
Angewandte Chemie - International Edition, 2010 , vol. 49, # 24 p. 4067 - 4070
反应条件
1: 4-bromo-aniline With tert.-butylnitrite; boron trifluoride diethyl etherate in tetrahydrofuran
T=-15 - 20°C; Inert atmosphere;
2: phenylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetra-(n-butyl)ammonium iodide; diethylamine in acetonitrile
T=20°C; Sonogashira coupling; 3 h;
参考文献
Fabrizi, Giancarlo; Goggiamani, Antonella; Sferrazza, Alessio; Cacchi, Sandro
Angewandte Chemie - International Edition, 2010 , vol. 49, # 24 p. 4067 - 4070
反应条件
in tetrahydrofuran; toluene
T=-45 - 20°C;
参考文献
Katritzky, Alan R.; Abdel-Fattah, Ashraf A. A.; Wang, Mingyi
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7526 - 7529
反应条件
1: CuI; triethylamine / Pd(Ph3P)2Cl2 / tetrahydrofuran / 1 h / 20 °C
2: potassium hydroxide / H2O; methanol; CHCl3 / 0.5 h / 20 °C
3: 83 percent / CuI; triethylamine / Pd(Ph3P)2Cl2 / 2 h / Heating
View Scheme
参考文献
Yamaguchi, Yoshihiro; Ochi, Takanori; Wakamiya, Tateaki; Matsubara, Yoshio; Yoshida, Zen-Ichi
Organic Letters, 2006 , vol. 8, # 4 p. 717 - 720
反应条件
1: potassium hydroxide / H2O; methanol; CHCl3 / 0.5 h / 20 °C
2: 83 percent / CuI; triethylamine / Pd(Ph3P)2Cl2 / 2 h / Heating
View Scheme
参考文献
Yamaguchi, Yoshihiro; Ochi, Takanori; Wakamiya, Tateaki; Matsubara, Yoshio; Yoshida, Zen-Ichi
Organic Letters, 2006 , vol. 8, # 4 p. 717 - 720
反应条件
palladium diacetate; dimethyl sulfoxide
T=20°C; Sonogashira Cross-Coupling; 0.0833333 h;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Dughera, Stefano
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 598 - 605
反应条件
palladium diacetate; dimethyl sulfoxide
T=20°C; Sonogashira Cross-Coupling; 0.0833333 h;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Dughera, Stefano
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 598 - 605
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran
T=40°C; 12 h;
参考文献
Kamikawa, Takashi; Hayashi, Tamio
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8922 - 8925
反应条件
dichlorolt;(2-dimethylamino)propyldiphenylphosphinegt;palladium; lithium bromide in diethyl ether; toluene
T=20°C; 3 h;
参考文献
Kamikawa, Takashi; Hayashi, Tamio
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8922 - 8925
反应条件
copper(l) iodide; 8-hydroxy-quinoline; caesium carbonate in N,N-dimethyl-formamide
T=110°C; Sonogashira coupling; 24 h; Inert atmosphereCombinatorial reaction / High throughput screening (HTS); Reactivity; Concentration;
参考文献
Wu, Minyan; Mao, Jincheng; Guo, Jun; Ji, Shunjun
European Journal of Organic Chemistry, 2008 , # 23 p. 4050 - 4054
