N-Cbz-3(S)-氟吡咯烷合成路线 (共 3 条)
反应条件
4,4'-diaminostilbene-2,2'-disulfonic acid in dichloromethane T=-78 - 20°C;
参考文献
MERCK and CO., INC.
Patent: WO2004/43940 A1, 2004 ;
Location in patent: Page 46 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; Xtalfluor-E® in dichloromethane T=-78 - 20°C; 24 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Lheureux, Alexandre; Beaulieu, Francis; Bennett, Christopher; Bill, David R.; Clayton, Simon; Laflamme, Franois; Mirmehrabi, Mahmoud; Tadayon, Sam; Tovell, David; Couturier, Michel
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3401 - 3411
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
MERCK and CO., INC.
Patent: WO2005/116029 A1, 2005 ;
Location in patent: Page/Page column 49-50 ;
WO 2005/116029 A1