甲基2-羟基-3-苯丙酸酯合成路线 （共 8 条）
反应条件
1: (S)-2-Hydroxy-3-phenylpropionic acid, methyl ester With pyridine; trifluoromethylsulfonic anhydride in dichloromethane 2: ethanol With sodium tetrahydroborate T=20°C; 0.25 h;
参考文献
Tetrahedron Letters, , vol. 43, # 9 p. 1657 - 1660
反应条件
water; chymotrypsin T=25°C; Rate constant;
参考文献
Gerisch; Jakubke; Kreuzfeld
Tetrahedron Asymmetry, 1995 , vol. 6, # 12 p. 3039 - 3045
反应条件
water; bovine carbonic anhydrase T=25°C; Bovine carbonic anhydrase catalyzed hydrolysis;
参考文献
Chenevert, Robert; Letourneau, Martin
Canadian Journal of Chemistry, 1990 , vol. 68, p. 314 - 316
反应条件
lipase in di-isopropyl ether T=35°C; Acetylation; resolution of racemate; Title compound not separated from byproducts;
参考文献
Yamano, Toru; Kikumoto, Fumio; Yamamoto, Shozo; Miwa, Katsuhiko; Kawada, Mitsuru; Ito, Tatsuya; Ikemoto, Tomomi; Tomimatsu, Kiminori; Mizuno, Yukio
Chemistry Letters, 2000 , # 5 p. 448 - 449
反应条件
water; bovine carbonic anhydrase T=25°C; Bovine carbonic anhydrase catalyzed hydrolysis;
参考文献
Chenevert, Robert; Letourneau, Martin
Canadian Journal of Chemistry, 1990 , vol. 68, p. 314 - 316
反应条件
lipase in di-isopropyl ether T=35°C; Acetylation; resolution of racemate; Title compound not separated from byproducts;
参考文献
Yamano, Toru; Kikumoto, Fumio; Yamamoto, Shozo; Miwa, Katsuhiko; Kawada, Mitsuru; Ito, Tatsuya; Ikemoto, Tomomi; Tomimatsu, Kiminori; Mizuno, Yukio
Chemistry Letters, 2000 , # 5 p. 448 - 449
反应条件
lipase PS-30 in toluene T=25°C; 96 h; Molecular sieveEnzymatic reaction; Overall yield = 40 percent; stereoselective reaction;
参考文献
Chen, Peiran; Yang, Wenhong
Tetrahedron Letters, 2014 , vol. 55, # 14 p. 2290 - 2294
反应条件
1: Et3N, 4-N,N-dimethylaminopyridine / various solvent(s) / 6 h / 60 °C
2: 51 percent / potassium fluoride / formamide / 2 h / 87 °C
3: 90 percent / formic acid
View Scheme
参考文献
Fritz-Langhals, Elke; Schuetz, Gabi
Tetrahedron Letters, 1993 , vol. 34, # 2 p. 293 - 296
