2-羟基-6-甲氧基喹啉合成路线 （共 17 条）
反应条件
triethylamine; p-toluenesulfonyl chloride in chloroform; water 12 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 28, # 2 p. 493 - 499
反应条件
1.1: phosphorus oxytribromide / 2.5 h / 60 - 140 °C 2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C 2.2: 2 h / -78 °C View Scheme
参考文献
MERCK SHARP and DOHME CORP.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L.; MCCAULEY, John, A.; LIVERTON, Nigel, J.; RUDD, Michael, T.; GILBERT, Kevin, F.; FERRARA, Marco; SUMMA, Vincenzo; CRESCENZI, Benedetta
Patent: WO2012/40040 A1, 2012 ;
WO 2012/040040 A1
反应条件
trichlorophosphate T=60°C;
参考文献
Inglis, Steven R.; Stojkoski, Cvetan; Branson, Kim M.; Cawthray, Jacquie F.; Fritz, Daniel; Wiadrowski, Emma; Pyke, Simon M.; Booker, Grant W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 22 p. 5405 - 5417
反应条件
hydrogen bromide in water 48 h; Heating;
参考文献
Seyedi, Seyed Mohammad; Sadeghian, Hamid; Arghiani, Zahra
Heterocyclic Communications, 2008 , vol. 14, # 3 p. 183 - 186
反应条件
phosphorus oxytribromide
T=60 - 140°C; 2.5 h;
参考文献
MERCK SHARP and DOHME CORP.; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L.; MCCAULEY, John, A.; LIVERTON, Nigel, J.; RUDD, Michael, T.; GILBERT, Kevin, F.; FERRARA, Marco; SUMMA, Vincenzo; CRESCENZI, Benedetta
Patent: WO2012/40040 A1, 2012 ;
Location in patent: Page/Page column 44-45 ;
WO 2012/040040 A1
反应条件
1: trichlorophosphate / 2 h / Reflux
2: boron tribromide / dichloromethane / 2 h / 0 - 25 °C
View Scheme
参考文献
N30 PHARMACEUTICALS, LLC; SUN, Xicheng; QIU, Jian; STOUT, Adam
Patent: WO2012/83165 A1, 2012 ;
