1-[2-硝基-4-(三氟甲基)苯基]-1H-吡咯合成路线 （共 3 条）
反应条件
acetic acid T=115°C; 1 h;
参考文献
Campiani; Nacci; Corelli; Anzini
Synthetic Communications, 1991 , vol. 21, # 15-16 p. 1567 - 1576
反应条件
copper(l) iodide; (E)-1-(2-hydroxyphenyl)-3-(N,N-dimethylamino)prop-2-en-1-one; caesium carbonate in acetonitrile T=82°C; Ullmann type coupling; 12 h; Inert atmosphere;
参考文献
Cheng, Cungui; Sun, Gonglei; Wan, Jieping; Sun, Cuirong
Synlett, 2009 , # 16 p. 2663 - 2668
反应条件
2: 66 percent / 85percent KOH / 2-methyl-propan-2-ol / 1 h / 80 °C 3: 84 percent / K2CO3 / dimethylformamide / 1.5 h / 135 °C 4: 72 percent / POCl3 / 4 h / 120 °C View Scheme
参考文献
Campiani; Nacci; Corelli; Anzini
Synthetic Communications, 1991 , vol. 21, # 15-16 p. 1567 - 1576
