(-)-2β-甲酯基-3β-(4-碘苯基)去甲托烷合成路线

参考文献

GE HEALTHCARE LIMITED; WILLIAMS, Lorenzo; KEILEN, Gunnar; HAUGAN, Jarle Andre
Patent: WO2011/73256 A1, 2011 ;
Location in patent: Page/Page column 13 ;

352-91-01-溴-3-氟丙烷+

136794-87-1(-)-2β-甲酯基-3β-(4-碘苯基)去甲托烷

155797-99-2(1R,2S,3S)-8-(3-氟丙基)-3-(4-碘苯基)-8-氮杂双环[3.2.1]辛烷-2-羧酸甲酯

参考文献

Gu, Xiao-Hui; Zong, Rushi; Kula, Nora S.; Baldessarini, Ross J.; Neumeyer, John L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3049 - 3053

762-49-21-溴-2-氟乙烷+

136794-87-1(-)-2β-甲酯基-3β-(4-碘苯基)去甲托烷

155798-01-95S)-8-(2-氟乙基)-3-(4-碘苯基)-8-氮杂双环[3.2.1]辛烷-2-羧酸甲酯(1R2S3S

参考文献

Neumeyer; Wang; Gao; Milius; Kula; Campbell; Baldessarini; Zea-Ponce; Baldwin; Innis
Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1558 - 1561

135416-43-2(1R,2S,3S,5S)-3-(4-碘苯基)-8-甲基-8-氮杂双环[3.2.1]辛烷-2-羧酸甲酯

136794-87-1(-)-2β-甲酯基-3β-(4-碘苯基)去甲托烷

参考文献

Tamagnan, Gilles; Alagille, David; Fu, Xing; Kula, Nora S.; Baldessarini, Ross J.; Innis, Robert B.; Baldwin, Ronald M.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1131 - 1133

50372-80-0(1R,2S,3S,5S)-8-甲基-3-苯基-8-氮杂双环[3.2.1]辛烷-2-羧酸甲酯

136794-87-1(-)-2β-甲酯基-3β-(4-碘苯基)去甲托烷

参考文献

Boja; Kuhar; Kopajtic; Yang; Abraham; Lewin; Carroll
Journal of medicinal chemistry, 1994 , vol. 37, # 8 p. 1220 - 1223

174224-35-2

136794-87-1(-)-2β-甲酯基-3β-(4-碘苯基)去甲托烷

参考文献

Gu, Xiao-Hui; Zong, Rushi; Kula, Nora S.; Baldessarini, Ross J.; Neumeyer, John L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3049 - 3053

17878-43-2

136794-87-1(-)-2β-甲酯基-3β-(4-碘苯基)去甲托烷

参考文献

Gu, Xiao-Hui; Zong, Rushi; Kula, Nora S.; Baldessarini, Ross J.; Neumeyer, John L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3049 - 3053