1: 83 percent / K2CO3 / acetonitrile / 17 h / 75 °C 2: 89 percent / Pd, NH3, PPh3 / toluene / 14 h / 100 °C / other reagent, reaction time 3: 82 percent / NaOH / ethanol; H2O / 4 h / 80 °C 4: 62 percent / MnO2 / CH2Cl2; acetic acid / 5.5 h / -10 °C / other reagent, solvent, temperature, reaction time View Scheme