6-氟-1H-吲哚-2-羧酸甲酯合成路线 （共 11 条）
反应条件
hydrogenchloride; iron in ethanol; water T=0°C; 5 h; Heating / reflux;
参考文献
US2005/96321 A1, ;
Page/Page column 5 ;
反应条件
in toluene T=200°C; 0.166667 h; Microwave irradiation;
参考文献
Ranasinghe, Nadeesha; Jones, Graham B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1740 - 1742
反应条件
copper(I) oxide; caesium carbonate in 1-methyl-pyrrolidin-2-one T=100°C; 16 h; Inert atmosphereSealed tube;
参考文献
Zhu, Zhiqiang; Yuan, Jiangjun; Zhou, Yirong; Qin, Yang; Xu, Jingshi; Peng, Yiyuan
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 511 - 514
反应条件
1: With sodium methylate in methanol T=-20 - 4°C; 14 h; 2: in xylene Heating; Further stages.;
参考文献
Bozilovic, Jelena; Engels, Joachim W.
Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 8-9 p. 869 - 871
反应条件
1: With sodium methylate T=-20 - 4°C; 14 h; 2: in xylene Heating; Further stages.;
参考文献
Bozilovic, Jelena; Bats, Jan W.; Engels, Joachim W.
Canadian Journal of Chemistry, 2007 , vol. 85, # 4 p. 283 - 292
反应条件
1: 91 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH2Cl2 / 2 h / 20 °C 2: 16 percent / K2CO3; L-proline / CuI / dioxane / 24 h / 100 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 51 p. 8877 - 8880
反应条件
1: NaOMe / methanol / -20 - -8 °C 2: xylene / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 24 p. 4701 - 4710
反应条件
1: 99 percent / aq. NaOH / 2.5 h / Heating 2: 61 percent / copper; N-methylpyrrolidinone / 240 °C View Scheme
参考文献
Blair; Kurrasch-Orbaugh; Marona-Lewicka; Gumbay; Watts; Barker; Nichols
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4701 - 4710
反应条件
sodium hydroxide 2.5 h; Heating;
参考文献
Bozilovic, Jelena; Engels, Joachim W.
Nucleosides, Nucleotides and Nucleic Acids, 2007 , vol. 26, # 8-9 p. 869 - 871
反应条件
1: 6-fluoro-1H-indole-2-carboxylic acid ethyl ester; methyl 6-fluoroindole-2-carboxylate With sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 2 h;
2: methyl iodide in DMF (N,N-dimethyl-formamide)
T=20°C; 12 h;
参考文献
Froissant, Jacques; Marabout, Benoit; Marguet, Frank; Puech, Frederic
Patent: US2005/124615 A1, 2005 ;
Location in patent: Page/Page column 4 ;
