2-(3-硝基苯基)-1H-咪唑合成路线 （共 12 条）
反应条件
1: 3-cyano-1-nitrobenzene With sodium methylate in methanol 5 h; 2: 2-aminoacetaldehyde dimethyl acetal With acetic acid in methanol T=70°C; 1 h; 3: With hydrogenchloride in methanol; water T=70°C; 3 h;
参考文献
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; HAH, Jung-Mi; YOO, Kyung Ho; SIM, Tae-Bo; OH, Chang Hyun; LEE, Jung Hun; YU, Hana; KIM, Hwan
Patent: WO2011/49274 A1, 2011 ;
Location in patent: Page/Page column 17 ;
WO 2011/049274 A1
反应条件
ammonia; sodium acetate in methanol T=20°C; 16 h;
参考文献
WO2006/17443 A2, ;
Page/Page column 176-177 ;
WO 2006/017443 A2
反应条件
hydrogenchloride in methanol; water
反应条件
1: 3-nitro-aniline With hydrogenchloride; sodium nitrite in water T=0 - 10°C; 2: 1H-imidazole With sodium acetate T=5 - 20°C;
参考文献
Sharma, Deepika; Narasimhan, Balasubramanian; Kumar, Pradeep; Judge, Vikramjeet; Narang, Rakesh; De Clercq, Erik; Balzarini, Jan
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2347 - 2353
反应条件
1: sodium methylate / 17 h / 20 °C / Inert atmosphere 2: 1 h / 50 °C / Inert atmosphere 3: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 21 p. 7664 - 7674
反应条件
1: 1 h / 50 °C / Inert atmosphere 2: hydrogenchloride / water / 5 h / Reflux; Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 53, # 21 p. 7664 - 7674
反应条件
T=0 - 10°C; 5 h; Irradiation; Yield given. Yields of byproduct given;
参考文献
Chemistry Letters, , p. 1489 - 1492
参考文献
Journal of the Chemical Society, , vol. 125, p. 2487
参考文献
Journal of the Chemical Society, , vol. 125, p. 2487
参考文献
Journal of the Chemical Society, , vol. 125, p. 2487
