2-羟基-4-硝基苯甲酸甲酯合成路线 （共 18 条）
反应条件
sulfuric acid T=65°C; 96 h; Inert atmosphere;
参考文献
Prabhakaran, Panchami; Azzarito, Valeria; Jacobs, Tia; Hardie, Michaele J.; Kilner, Colin A.; Edwards, Thomas A.; Warriner, Stuart L.; Wilson, Andrew J.
Tetrahedron, 2012 , vol. 68, # 23 p. 4485 - 4491
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=20°C; 1 h;
参考文献
IRM LLC; NOVARTIS, AG
Patent: WO2007/38669 A2, 2007 ;
Location in patent: Page/Page column 171 ;
反应条件
in methanol; hexane; toluene T=20°C; 1.25 h;
参考文献
SCHERING AG
Patent: WO2005/89815 A2, 2005 ;
Location in patent: Page/Page column 27 ;
反应条件
thionyl chloride in methanol T=0°C; 6 h; Reflux;
参考文献
Matsuo, Kazuya; Kamada, Rui; Mizusawa, Keigo; Imai, Hirohiko; Takayama, Yuki; Narazaki, Michiko; Matsuda, Tetsuya; Takaoka, Yousuke; Hamachi, Itaru
Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12875 - 12883
反应条件
1: With potassium carbonate in acetone 24 h; 2: With hydrogenchloride; water in ethyl acetate pH=3;
参考文献
CEPHALON, INC.; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2008/51547 A1, 2008 ;
Location in patent: Page/Page column 552 ;
WO 2008/051547 A1
反应条件
1: 97 percent / BBr3 / CH2Cl2 2: 95 percent / SOCl2 View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
参考文献
Kaur, Gurmeet; Narayanan, Ven L.; Risbood, Prabhakar A.; Hollingshead, Melinda G.; Stinson, Sherman F.; Varma, Ravi K.; Sausville, Edward A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1749 - 1761
反应条件
1,4-dioxane; diethyl ether
参考文献
Hueckel; Janecka
Archiv der Pharmazie (Weinheim, Germany), 1951 , vol. 284, p. 341,346
反应条件
1: platinum; ethanol / Hydrogenation 2: chloroform View Scheme
参考文献
Drain et al.
Journal of the Chemical Society, 1949 , p. 1498,1502
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3597 - 3600
