2-羟基-4-硝基苯甲酸甲酯合成路线 （共 18 条）
反应条件
1: diethyl ether; methanol 2: SnCl2; concentrated aqueous HCl View Scheme
参考文献
Hueckel; Janecka
Archiv der Pharmazie (Weinheim, Germany), 1951 , vol. 284, p. 341,346
反应条件
1: platinum; ethanol / Hydrogenation 2: hydrazine hydrate View Scheme
参考文献
Drain et al.
Journal of the Chemical Society, 1949 , p. 1498,1502
反应条件
1: H2 / Pd/C 2: H2 / Pd/C View Scheme
参考文献
Kaur, Gurmeet; Narayanan, Ven L.; Risbood, Prabhakar A.; Hollingshead, Melinda G.; Stinson, Sherman F.; Varma, Ravi K.; Sausville, Edward A.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1749 - 1761
反应条件
1: 98 percent / H2 / Pd/C / ethyl acetate
2: 58 percent / H2 / Rh/Al / acetic acid / 70 h / 58 °C / 2740.88 Torr
3: 80 percent / 1,3,5-trimethyl-benzene / 165 °C
4: 98 percent / LAH / tetrahydrofuran / Heating
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
triethylamine in chloroform
参考文献
Pharmacia AB
Patent: US4591584 A1, 1986 ;
反应条件
1: 98 percent / H2 / Pd/C / ethyl acetate
2: 58 percent / H2 / Rh/Al / acetic acid / 70 h / 58 °C / 2740.88 Torr
3: 80 percent / 1,3,5-trimethyl-benzene / 165 °C
4: 98 percent / LAH / tetrahydrofuran / Heating
5: 96 percent / PDC / CH2Cl2
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1: 98 percent / H2 / Pd/C / ethyl acetate
2: 58 percent / H2 / Rh/Al / acetic acid / 70 h / 58 °C / 2740.88 Torr
3: 80 percent / 1,3,5-trimethyl-benzene / 165 °C
4: 98 percent / LAH / tetrahydrofuran / Heating
5: 96 percent / PDC / CH2Cl2
6: 61 percent / tetrahydrofuran / 0 °C
7: 88 percent / H2 / PtO2 / ethyl acetate
8: 99 percent / TFA
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
methanol; diethyl ether
参考文献
Hueckel; Janecka
Archiv der Pharmazie (Weinheim, Germany), 1951 , vol. 284, p. 341,346
