5-氯-1,3-二氢-2H-吡咯并[3,2-b]吡啶-2-酮合成路线 （共 4 条）
反应条件
1: With hydrogen in ethanol; water P=2280.15 Torr; 48 h; 2: With hydrogenchloride in water 5 h; Reflux;
参考文献
Hoffmann-La Roche Inc.; Alam, Muzaffar; Du Bois, Daisy Jo; Hawley, Ronald Charles; Minatti, Ana Elena; Kennedy-Smith, Joshua; Thakkar, Kshitij Chhabilbhai; Wilhelm, Robert Stephen
Patent: US2013/158066 A1, 2013 ;
Location in patent: Paragraph 0169 ;
反应条件
hydrogenchloride; hydrogen; sodium hydride; nickel Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 33, # 2 p. 287 - 293
反应条件
1.1: sodium hydride / ethylene glycol dimethyl ether / 2 h / 20 °C 1.2: 18 h / 20 °C 2.1: hydrogen / ethanol; water / 48 h / 2280.15 Torr 2.2: 5 h / |Reflux View Scheme
反应条件
borane-THF in tetrahydrofuran T=60°C; 3 h;
参考文献
WO2010/149685 A1, ;
Page/Page column 52; 53 ;
WO 2010/149685 A1
