2-氯-3-硝基-5-氟吡啶合成路线 （共 6 条）
反应条件
N-benzyl-N,N,N-trimethyl-ammonium chloride; trichlorophosphate in acetonitrile T=80°C; 6 h;
参考文献
Ahn, Sung Oh; Park, Chan Hee; Im, Jun Hwan; Lee, Soon Ok; Lee, Kyoung June; Cho, Seong Wook; Ko, Kwang Seok; Han, Sun Young; Lee, Won Il
Patent: US2011/28467 A1, 2011 ;
Location in patent: Page/Page column 52 ;
US 20110028467 A1
反应条件
1: With hydrogenchloride; sodium nitrite in water T=-15 - 20°C; 2.16667 h; 2: With sodium hydroxide in water cooling with ice;
参考文献
EP2471792 A1, ;
Page/Page column 39-40 ;
反应条件
1.1: sulfuric acid / 0.17 h / cooling with ice 1.2: 3 h / 20 - 55 °C / cooling with ice 2.1: hydrogenchloride; sodium nitrite / water / 2.17 h / -15 - 20 °C 2.2: cooling with ice View Scheme
反应条件
1: 11 percent / conc. H2SO4, HNO3 / 3.5 h / 55 - 60 °C 2: 37 percent / PCl5, POCl3 / 100 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 33, # 2 p. 287 - 293
反应条件
iron; ammonium chloride in tetrahydrofuran; ethanol; water 5 h; Reflux;
参考文献
Astellas Pharma Inc.
Patent: EP2394987 A1, 2011 ;
Location in patent: Page/Page column 10 ;
反应条件
1: 1.) NaH / 1.) DMF, RT, 0.25 h, 2.) DMF, 0 deg C, 0.25 h
2: H2 / Raney nickel / aq. ethanol / 2280 Torr
3: 6 N HCl / 3 h / Heating
View Scheme
参考文献
Robinson, Ralph P.; Donahue, Kathleen M.; Son, Paul S.; Wagy, Steven D.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 2 p. 287 - 293
