2,4,5-三氟-3-甲氧基苯甲酸甲酯合成路线 （共 6 条）
反应条件
sodium hydride in N,N-dimethyl-formamide 18 h;
参考文献
Sanchez, Joseph P.; Gogliotti, Rocco D.; Domagala, John M.; Gracheck, Stephen J.; Huband, Michael D.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4478 - 4487
参考文献
Hoechst Aktiengesellschaft
Patent: US5744628 A1, 1998 ;
反应条件
sodium hydroxide in methanol 3 h; Ambient temperature;
参考文献
Sanchez, Joseph P.; Gogliotti, Rocco D.; Domagala, John M.; Gracheck, Stephen J.; Huband, Michael D.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4478 - 4487
反应条件
1: aq. NaOH / methanol 2: (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Sanchez, Joseph P.; Gogliotti, Rocco D.; Domagala, John M.; Gracheck, Stephen J.; Huband, Michael D.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4478 - 4487
反应条件
1: 61 percent / 1.0 N aq. NaOH / methanol / 3 h / Ambient temperature 2: oxalyl chloride, DMF / CH2Cl2 / 18 h / Ambient temperature 3: 1.) n-BuLi, 2,2'-bipyridyl / 1.) THF, hexane, from -20 deg C to -5 deg C, 2.) THF, hexane, -30 deg C, 2 h 4: acetic anhydride / 22 h / Heating 5: ethanol / 18 h / Ambient temperature 6: 81 percent / NaH / tetrahydrofuran / 18 h View Scheme
参考文献
Sanchez, Joseph P.; Gogliotti, Rocco D.; Domagala, John M.; Gracheck, Stephen J.; Huband, Michael D.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4478 - 4487
反应条件
1.1: aq. NaOH / methanol 2.1: (COCl)2; DMF / CH2Cl2 3.1: MgCl2; Et3N / acetonitrile / 20 - 25 °C 3.2: Et3N / acetonitrile / 18 h / 20 °C View Scheme
参考文献
Sanchez, Joseph P.; Gogliotti, Rocco D.; Domagala, John M.; Gracheck, Stephen J.; Huband, Michael D.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 22 p. 4478 - 4487
