1.1: n-butyllithium / tetrahydrofuran / 3 h / 0 °C
1.2: 3 h / 0 °C
2.1: 1-methyl-pyrrolidin-2-one / 36 h / 220 °C / Inert atmosphere
3.1: hydrogenchloride; ethanol / 12 h / 80 °C
View Scheme
参考文献
RADIUS HEALTH, INC.; MILLER, Chris, P.
Patent: WO2012/47617 A1, 2012 ;
WO 2012/047617 A1
