136918-14-4合成路线 （共 708 条）
反应条件
1: phthalimide With potassium hydroxide; Amberlite IRA-400 chloride form 2: 1,6-dibromo-n-hexane in tetrahydrofuran Heating;
参考文献
Dalal; Pawar; Mahulikar
Organic Preparations and Procedures International, 2007 , vol. 39, # 1 p. 81 - 85
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Kowalski, Piotr; Mitka, Katarzyna; Jaskowska, Jolanta; Duszynska, Beata; Bojarski, Andrzej J.
Archiv der Pharmazie, 2013 , vol. 346, # 5 p. 339 - 348
反应条件
1: phthalimide With potassium hydroxide; Amberlite IRA-400 chloride form 2: 1,3-dibromo-propane in tetrahydrofuran Heating;
参考文献
Dalal; Pawar; Mahulikar
Organic Preparations and Procedures International, 2007 , vol. 39, # 1 p. 81 - 85
反应条件
1: potassium carbonate / H2O; methanol / 2 h / Heating 2: 60 percent / H2SO4 / 1 h / 20 °C View Scheme
参考文献
Pandey; Gupta; Upadhyay, Mrinalini; Upadhyay, Mridula; Singh; Tandon, Meenal
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 1 p. 158 - 162
反应条件
Erhitzen des erhaltenen N-Methyl-phthalimids mit wss.H2SO4 oder NaOH auf 150-160grad;
参考文献
DE523693 , ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 342
反应条件
1,4-dioxane; nickel T=160°C; P=102971 Torr; Hydrogenation;
参考文献
Dunet et al.
Bulletin de la Societe Chimique de France, 1956 , p. 906,910
反应条件
in chloroform T=20°C; 4 h;
参考文献
Vatulina, G. G.; Tuzhilkova, T. N.; Matveeva, T. V.; Krasnov, V. P.; Burde, N. L.; Alekseeva, L. V.
Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 9 p. 647 - 653
Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 9 p. 1078 - 1083
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=0 - 25°C; 12 h; Inert atmosphere;
参考文献
Principia Biopharma Inc.; Goldstein, David Michael
Patent: US8673925 B1, 2014 ;
Location in patent: Page/Page column 251 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 18 h;
参考文献
Fletcher, David I.; Ganellin, C. Robin; Piergentili, Alessandro; Dunn, Philip M.; Jenkinson, Donald H.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 16 p. 5457 - 5479
反应条件
1: triethylamine / 4 h / 0 - 20 °C 2: potassium carbonate / water / 2 h / 20 °C View Scheme
参考文献
TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan
Patent: WO2013/13188 A1, 2013 ;
WO 2013/013188 A1
