136918-14-4合成路线 （共 708 条）
反应条件
1.1: triphenylphosphine; sodium acetate / toluene / 0.17 h / Heating 1.2: 78 percent / acetic acid / toluene / 18 h / Heating 2.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C 2.2: 58 percent / tetrahydrofuran / 0.33 h / Heating 3.1: 6 percent sodium amalgam; sodium phosphate / methanol / 1 h / 20 °C 4.1: 34 mg / ceric ammonium nitrate / acetonitrile; H2O / 5 h View Scheme
参考文献
Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen
Synthetic Communications, 2003 , vol. 33, # 8 p. 1375 - 1382
反应条件
1: 90 percent / NaOEt / ethyl acetate; ethanol / 1.) RT, 2 h, 2.) reflux, 2 h 2: 52 percent / Br2 / methanol / 24 h / Ambient temperature View Scheme
参考文献
Eriks; Van der Goot; Sterk; Timmerman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3239 - 3246
反应条件
1: With potassium carbonate in DMF (N,N-dimethyl-formamide) T=20 - 80°C; 18 - 24 h; 2: With water in DMF (N,N-dimethyl-formamide) T=0 - 5°C; 1 h;
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/93239 A2, 2003 ;
Location in patent: Page/Page column 7 ;
反应条件
1: potassium carbonate; TEBA / acetonitrile / 0.1 h / Heating; microwave irradiation 2: potassium carbonate / acetonitrile / 0.1 h / Heating; microwave irradiation View Scheme
参考文献
Kuang, Yunyan; Huang, Jian; Chen, Fener
Synthetic Communications, 2006 , vol. 36, # 11 p. 1515 - 1519
反应条件
in toluene 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
BIOVITRUM AB
Patent: WO2005/75471 A2, 2005 ;
Location in patent: Page/Page column 127 ;
WO 2005/075471 A2
反应条件
1.1: sulfuryl dichloride; triethylamine / dichloromethane / 0 - 20 °C 1.2: 1 h / 0 - 20 °C 2.1: palladium diacetate / trifluoroacetic acid / 6 h / 20 °C View Scheme
参考文献
Saravanan, Perumal; Anbarasan, Pazhamalai
Organic Letters, 2014 , vol. 16, # 3 p. 848 - 851
反应条件
methanol; mercury(II) orthophosphate; boron trifluoride T=175°C; P=12871.4 Torr; Herstellung konnte von Furukawa, Onishi (2. Zit.) nicht reproduziert werden;
参考文献
US2231887 , ;
Bl. Inst. chem. Res. Kyoto Univ., , vol. 25, p. 74
反应条件
copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in toluene T=113°C; 16 h;
参考文献
Journal of Organic Chemistry, , vol. 73, # 7 p. 2621 - 2632
反应条件
Na2[PdCl4] Substitution; vinylation; 8 h; Heating;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1507 - 1516
反应条件
tetrabutyl ammonium fluoride; copper diacetate in 1,4-dioxane; methanol; dichloromethane T=30°C;
参考文献
Mendeleev Communications, , vol. 21, # 6 p. 326 - 328
