136918-14-4合成路线 （共 708 条）
反应条件
sulfuric acid; hydrogen bromide T=80°C; 1 h;
参考文献
Chinese Chemical Letters, , vol. 22, # 10 p. 1159 - 1162
反应条件
1: 97 percent / DMAP / acetonitrile / 0.5 h / 20 °C 2: 95 percent / 50 percent aq. NH2OH / acetonitrile / 20 °C View Scheme
参考文献
Bretschneider
Journal fuer Praktische Chemie (Leipzig), 1897 , vol. <2> 55, p. 293
反应条件
1: NH2NH2•xH2O / ethanol / 70 °C / |Cooling with ice 2: trichlorophosphate / ethanol / 4 h / |Reflux 3: NH2NH2•xH2O / ethanol / 60 °C View Scheme
参考文献
Wu, Yan; Sun, Liang-Peng; Ma, Long-Xu; Che, Jian; Song, Ming-Xia; Cui, Xun; Piao, Hu-Ri
Chemical Biology and Drug Design, 2013 , vol. 81, # 5 p. 591 - 599
反应条件
titanium tetrachloride; zinc in tetrahydrofuran T=0°C; 12 h;
参考文献
Kise, Naoki; Kawano, Yusuke; Sakurai, Toshihiko
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12453 - 12459
反应条件
1: caesium carbonate / acetonitrile / 80 °C 2: 0.5 h / Microwave irradiation View Scheme
参考文献
Long, Timothy E.; Lu, Xiao; Galizzi, Melina; Docampo, Roberto; Gut, Jiri; Rosenthal, Philip J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2976 - 2979
反应条件
1: NaOCl / diethyl ether; H2O / 1 h / 0 °C 2: diethyl ether / 2 h / Ambient temperature View Scheme
参考文献
Hosay; Christiaens; Anthoine; Moniotte
Tetrahedron Letters, 1990 , vol. 31, # 6 p. 873 - 874
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu reaction; 3 h;
参考文献
Oves, Daniel; Fernandez, Susana; Ferrero, Miguel; Bouillon, Roger; Verstuyf, Annemieke; Gotor, Vicente
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 4 p. 928 - 937
反应条件
in N,N-dimethyl-formamide Gabriel Amine Synthesis;
参考文献
Pigza, Julie A.; Han, Jeong-Seok; Chandra, Aroop; Mutnick, Daniel; Pink, Maren; Johnston, Jeffrey N.
Journal of Organic Chemistry, 2013 , vol. 78, # 3 p. 822 - 843
反应条件
Mitsunobu conditions;
参考文献
Tiecco, Marcello; Testaferri, Lorenzo; Temperini, Andrea; Bagnoli, Luana; Marini, Francesca; Santi, Claudio; Terlizzi, Raffaella
European Journal of Organic Chemistry, 2004 , # 16 p. 3447 - 3458
反应条件
1: 65 percent / conc. HNO3, conc. H2SO4 2: 88 percent / H2 / Pd/C / ethyl acetate / 120 h / 20 °C / 1500.1 - 2550.2 Torr 3: 100 percent / NaOH, Zn, CuSO4 / H2O / 70 - 80 °C View Scheme
参考文献
Yang, Na; Wang, Qing-He; Wang, Wen-Qian; Wang, Jian; Li, Feng; Tan, Shen-Peng; Cheng, Mao-Sheng
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 53 - 56
