136918-14-4合成路线 （共 708 条）
反应条件
chiral phosphine-oxazoline ligand; [Pd2(dba)2] in tetrahydrofuran 12 h; Heating;
参考文献
Xu, Guopin; Gilbertson, Scott R
Tetrahedron Letters, 2002 , vol. 43, # 15 p. 2811 - 2814
反应条件
1: sulfuric acid; nitric acid 2: urea / 1 h / 180 - 200 °C View Scheme
参考文献
Pavaskar; Patil; Furtado; Salker
Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4300 - 4307
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=25°C; Mitsunobu reaction; 72 h;
参考文献
Hoertner, Simone R.; Ritschel, Tina; Stengl, Bernhard; Kramer, Christian; Schweizer, W. Bernd; Wagner, Bjoern; Kansy, Manfred; Klebe, Gerhard; Diederich, Francois
Angewandte Chemie - International Edition, 2007 , vol. 46, # 43 p. 8266 - 8269
反应条件
in N,N-dimethyl-formamide 12 h; Reflux;
参考文献
SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; LETALLEC, Jean-Philippe; MARCINIAK, Gilbert; RONAN, Baptiste; VIVET, Bertrand
Patent: WO2013/190510 A2, 2013 ;
Location in patent: Page/Page column 122-123 ;
反应条件
potassium fluoride on basic alumina in 2-methyl tetrahydrofuran T=90°C; 4 h; Inert atmosphere; chemoselective reaction;
参考文献
Pace, Vittorio; Hoyos, Pilar; Fernandez, Maria; Sinisterra, Jose V.; Alcantara, Andres R.
Green Chemistry, 2010 , vol. 12, # 8 p. 1380 - 1382
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; 1,3-bis-(diphenylphosphino)propane; sodium carbonate in toluene T=120°C; 10 h; Inert atmosphere; regioselective reaction;
参考文献
Banerjee, Debasis; Junge, Kathrin; Beller, Matthias
Angewandte Chemie - International Edition, 2014 , vol. 53, # 6 p. 1630 - 1635
Angew. Chem., 2014 , vol. 126, # 6 p. 1656 - 1661,6
反应条件
caesium carbonate; sodium iodide in N,N-dimethyl-formamide T=70°C; 0.166667 h; Microwave irradiation;
参考文献
Escudero, Mercedes Isasmendi; Kremenchuzky, Lautaro D.; Perillo, Isabel A.; Cerecetto, Hugo; Blanco, Maria M.
Synthesis, 2011 , # 4 art. no. M06310SS, p. 571 - 576
反应条件
1.1: water / 4 h / 100 °C 2.1: thionyl chloride / 4 h / 75 °C / Inert atmosphere 3.1: sodium iodide / acetone / 4 h / 20 °C / Darkness 4.1: copper(l) iodide; diethylzinc / hexane; dichloromethane / 2 h / 20 °C / Inert atmosphere 4.2: 4 h / 20 °C / Inert atmosphere View Scheme
参考文献
Maury, Julien; Mouysset, Dominique; Feray, Laurence; Marque, Sylvain R. A.; Siri, Didier; Bertrand, Michele P.
Chemistry - A European Journal, 2012 , vol. 18, # 11 p. 3241 - 3247
反应条件
[bis(acetoxy)iodo]benzene T=140°C; 4 h;
参考文献
Shrestha, Ruja; Mukherjee, Paramita; Tan, Yichen; Litman, Zachary C.; Hartwig, John F.
Journal of the American Chemical Society, 2013 , vol. 135, # 23 p. 8480 - 8483
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran Ambient temperature;
参考文献
Mantegani, Sergio; Brambilla, Enzo; Caccia, Carla; Damiani, Gabriele; Fornaretto, Maria Gioia; McArthur, Robert A.; Varasi, Mario
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1117 - 1122
