136918-14-4合成路线 （共 708 条）
反应条件
sodium hydride 1.) DMF, 2.) DMF, 90 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Ohno; Adachi; Koumori; Mizukoshi; Nagasaka; Ichihara; Kato -
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 7 p. 1463 - 1473
反应条件
1: ethanol; hydrazine hydrate / anschliessenden Erwaermen View Scheme
参考文献
Drew; Hatt
Journal of the Chemical Society, 1937 , p. 16,25
反应条件
sodium carbonate in methanol; water T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: US2011/118326 A1, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
triphenylphosphine; diethylazodicarboxylate Mitsunobu reaction;
参考文献
Ardeo, Ainhoa; Garcia, Eva; Arrasate, Sonia; Lete, Esther; Sotomayor, Nuria
Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8445 - 8448
反应条件
1: 80 percent / 1.) I2, conc. H2SO4, 2.) aq. NH3, 3.) (CF3CO)2O, pyridine / 1) 85-90 deg C, 24 h; 2) 50-60 deg C, 1.5 h; 3) dioxane, rt, overnight 2: 82 percent / triethylamine, Pd(PPh3)2Cl2 / 0.5 h / 110 °C 3: 95 percent / H2 / Pd on barium sulfate / ethanol / 1 h / 1861.7 Torr View Scheme
参考文献
Terekhov, Dmitri S.; Nolan, Kieran J. M.; McArthur, Colin R.; Leznoff, Clifford C.
Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 3034 - 3040
反应条件
tri-tert-butyl phosphine; [bis(acetoxy)iodo]benzene; palladium diacetate T=100°C; 33 h; Inert atmosphereCombinatorial reaction / High throughput screening (HTS)Glovebox; Overall yield = 72 percent; Overall yield = 210 mg;
参考文献
Shrestha, Ruja; Mukherjee, Paramita; Tan, Yichen; Litman, Zachary C.; Hartwig, John F.
Journal of the American Chemical Society, 2013 , vol. 135, # 23 p. 8480 - 8483
反应条件
1: With di-isopropyl azodicarboxylate; triphenylphosphine Gabriel synthesis; Inert atmosphere; 2: With hydrazine hydrate Gabriel synthesis; Inert atmosphere; 3: With hydrogenchloride in water Inert atmosphere;
参考文献
Tuchscherer, Andre; Schaarschmidt, Dieter; Schulze, Steffen; Hietschold, Michael; Lang, Heinrich
European Journal of Inorganic Chemistry, 2011 , # 28 p. 4421 - 4428
反应条件
xylene Hydrolyse des entstandenen N-<3-Diaethylamino-propyl>-phthalimids mit konz.HCl bei Siedetemperatur.;
参考文献
Amundsen; Sanderson
Org.Synth.Coll., 1955 , vol. Vol.III, p. 257
反应条件
potassium hydroxide in methanol; ethanol 1 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 133, # 41 p. 16410 - 16413
反应条件
triethylamine in N,N-dimethyl-formamide 1. 0-5 deg C, 90 min; 2. room temperature, 4 h;
参考文献
Worster, Paul M.; Leznoff, Clifford C.; McArthur, Colin R.
Journal of Organic Chemistry, 1980 , vol. 45, # 1 p. 174 - 175
