136918-14-4合成路线 （共 708 条）
反应条件
1: potassium hydroxide / 160 °C 2: acetone / 600 °C View Scheme
参考文献
Kogyo Kagaku Zasshi, , vol. 55, p. 83
Chem.Abstr., , p. 10272
反应条件
tri-tert-butyl phosphine; [bis(acetoxy)iodo]benzene; palladium diacetate T=100°C; 33 h; Inert atmosphereGlovebox; Overall yield = 82 percent; Overall yield = 247 mg;
参考文献
Shrestha, Ruja; Mukherjee, Paramita; Tan, Yichen; Litman, Zachary C.; Hartwig, John F.
Journal of the American Chemical Society, 2013 , vol. 135, # 23 p. 8480 - 8483
反应条件
hydrogenchloride; water 1.) 100 deg C, 4 h; 2.) 90 deg C, 50 h; Yield given. Multistep reaction;
参考文献
Riggio; Hopff; Hofmann; Waser
Helvetica Chimica Acta, 1980 , vol. 63, # 2 p. 488 - 497
反应条件
tetrabutylammomium bromide; potassium carbonate T=20°C; 1 h; Neat (no solvent);
参考文献
Jaskowska, Jolanta; Kowalski, Piotr
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 5 p. 1371 - 1375
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 48 h; Ambient temperature;
参考文献
Baraldi, P. G.; Guarneri, M.; Moroder, F.; Pollini, G. P.; Simoni, D.
Synthesis, 1982 , # 8 p. 653 - 655
反应条件
1: 71 percent / NEt3 / CH2Cl2 / 6 h / Heating 2: 85 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Gao, Jian; Guo, Yang Hui; Wang, Ya Ping; Wang, Xiang Jing; Xiang, Wen Sheng
Chinese Chemical Letters, 2011 , vol. 22, # 10 p. 1159 - 1162
反应条件
1: 99 percent / triethylbenzylammonium chloride, sodium, ethanol / 5 h / Heating 2: 80 percent / 5percent H2SO4 / Heating View Scheme
参考文献
Komarova, L. I.; Pokrovskaya-Dukhnenko, E. M.; Zaiko, I. A.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 11 p. 2089 - 2092
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 11 p. 2327 - 2331
反应条件
potassium carbonate T=90 - 110°C; 3 - 4 h;
参考文献
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Patent: EP1640367 A1, 2006 ;
Location in patent: Page/Page column 12-13 ;
反应条件
tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide in decane; ethyl acetate T=130°C; 3 h; Sealed tube;
参考文献
Lv, Yunhe; Li, Yan; Xiong, Tao; Lu, Yu; Liu, Qun; Zhang, Qian
Chemical Communications, 2014 , vol. 50, # 18 p. 2367 - 2369
反应条件
1: NaOEt / ethanol; ethyl acetate / Heating 2: 1.) Br2, 2.) 10.0M aq. H2SO4 / 1.) MeOH, from 0 deg C to RT, 2.) RT View Scheme
参考文献
ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; RICHARD-BILDSTEIN, Sylvia; SIEGRIST, Romain
Patent: WO2014/6585 A1, 2014 ;
