136918-14-4合成路线 （共 708 条）
反应条件
1.1: water / 4 h / 100 °C 2.1: thionyl chloride / 4 h / 75 °C / Inert atmosphere 3.1: sodium iodide / acetone / 4 h / 20 °C / Darkness 4.1: diethylzinc / hexane; dichloromethane / 18 h / 20 °C / Inert atmosphere 4.2: 4 h / Inert atmosphere View Scheme
参考文献
Maury, Julien; Mouysset, Dominique; Feray, Laurence; Marque, Sylvain R. A.; Siri, Didier; Bertrand, Michele P.
Chemistry - A European Journal, 2012 , vol. 18, # 11 p. 3241 - 3247
反应条件
potassium hydroxide; Aliquatreg; 336 in toluene T=100°C; 16 h;
参考文献
Santaniello, Enzo; Ponti, Federico
Synthetic Communications, 1980 , vol. 10, # 8 p. 611 - 614
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran Mitsunobu reaction;
参考文献
Proctor, Anthony J.; Beautement, Kevin; Clough, John M.; Knight, David W.; Li, Yingfa
Tetrahedron Letters, 2006 , vol. 47, # 29 p. 5151 - 5154
反应条件
in N,N-dimethyl-formamide T=120°C; 24 h;
参考文献
Inoue, Yoshio; Taguchi, Masaaki; Hashimoto, Harukichi
Synthesis, 1986 , # 4 p. 332 - 334
反应条件
sodium methylate in dimethyl sulfoxide 2 h; Ambient temperature;
参考文献
Hammen; Braisted; Northrup
Synthetic Communications, 1991 , vol. 21, # 21 p. 2157 - 2163
反应条件
1: ethanol; hydrazine hydrate / anschliessenden Erwaermen 2: ethanol View Scheme
参考文献
Drew; Hatt
Journal of the Chemical Society, 1937 , p. 16,25
反应条件
tetrabutylammomium bromide; potassium carbonate in N,N-dimethyl-formamide T=20°C; 14 h;
参考文献
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; THE BROAD INSTITUTE, INC.; HU, Longqin; MAGESH, Sadagopan; CHEN, Lin; LEWIS, Timothy; MUNOZ, Ben; WANG, Lili
Patent: WO2013/67036 A1, 2013 ;
Location in patent: Page/Page column 78; 79 ;
反应条件
[Cu(μ-OH)(tmeda)]2Cl2; caesium carbonate in acetonitrile T=20°C; 4 h;
参考文献
Kumaraswamy; Pitchaiah; Ramakrishna; Sadaiah
Tetrahedron Letters, 2006 , vol. 47, # 12 p. 2013 - 2015
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; Substitution; 2 h;
参考文献
Reyes, Adelfo; Regla, Ignacio; Fragoso, Mabel C.; Vallejo, Laura A.; Demare, Patricia; Jimenez-Vazquez, Hugo A.; Ramirez, Yara; Juaristi, Eusebio; Tamariz, Joaquin
Tetrahedron, 1999 , vol. 55, # 37 p. 11187 - 11202
反应条件
potassium carbonate T=160 - 165°C; 4 h;
参考文献
Schmid; Karrer
Helvetica Chimica Acta, 1948 , vol. 31, p. 1497,1500
Full Text Show Details
Griffin; Hey
Journal of the Chemical Society, 1952 , p. 3334,3337
