136918-14-4合成路线 （共 708 条）
反应条件
1: K2CO3 / dimethylformamide / 12 h / Heating 2: oxalyl chloride, DMSO, / CH2Cl2 / 30 h / -50 °C 3: Br2 / CCl4 / 3 h / Ambient temperature 4: dimethylformamide / 3 h / 120 °C View Scheme
参考文献
Eriks; Van der Goot; Sterk; Timmerman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3239 - 3246
反应条件
1: ethanethiol With chlorine in benzene T=0°C; 1 h; 2: phthalimide With N-ethyl-N,N-diisopropylamine in benzene T=0 - 20°C; 2 h;
参考文献
Heldreth, Bart; Long, Timothy E.; Jang, Seyoung; Reddy, G. Suresh Kumar; Turos, Edward; Dickey, Sonja; Lim, Daniel V.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 11 p. 3775 - 3784
反应条件
triethylamine in dichloromethane T=0 - 20°C; 1 h;
参考文献
Gillis, H. Martin; Greene, Lana; Thompson, Alison
Synlett, 2009 , # 1 p. 112 - 116
反应条件
1: 80 percent / 1.) I2, conc. H2SO4, 2.) aq. NH3, 3.) (CF3CO)2O, pyridine / 1) 85-90 deg C, 24 h; 2) 50-60 deg C, 1.5 h; 3) dioxane, rt, overnight 2: 85 percent / triethylamine, Pd(PPh3)2Cl2, CuI / 0.12 h / Ambient temperature View Scheme
参考文献
Terekhov, Dmitri S.; Nolan, Kieran J. M.; McArthur, Colin R.; Leznoff, Clifford C.
Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 3034 - 3040
反应条件
acetic acid T=140°C;
参考文献
Profft
Chemiker-Zeitung, Chemische Apparatur, 1957 , vol. 81, p. 427,429
反应条件
chiral (S)-proline-phosphine-oxazoline ligand; [Pd2(dba)2] in tetrahydrofuran T=0°C; 12 h;
参考文献
Chen, Junmin; Lang, Feng; Li, Dong; Cun, Linfeng; Zhu, Jin; Deng, Jingen; Liao, Jian
Tetrahedron Asymmetry, 2009 , vol. 20, # 17 p. 1953 - 1956
反应条件
1: rac-(E)-1,3-diphenylprop-2-en-1-yl acetate With bis(η3-allyl-μ-chloropalladium(II)); C47H50FeN3OP2(1+)*F6P(1-) in dichloromethane T=20°C; 0.25 h; Ionic liquidInert atmosphere; 2: phthalimide With potassium acetate; N,N-bis(trimethylsilyl)acetamide in dichloromethane T=20°C; 48 h; Ionic liquidInert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Sebesta, Radovan; Bilcik, Filip
Tetrahedron Asymmetry, 2009 , vol. 20, # 16 p. 1892 - 1896
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; C35H38FeN2P(1+)*I(1-) in N,N-dimethyl-formamide T=20°C; 2 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Yuan, Hao; Zhou, Zhiming; Xiao, Jiangliang; Liang, Lixuan; Dai, Li
Tetrahedron Asymmetry, 2010 , vol. 21, # 15 p. 1874 - 1884
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; 1,3-bis-(diphenylphosphino)propane; sodium carbonate in toluene T=140°C; 20 h; Inert atmosphere; regioselective reaction;
参考文献
Banerjee, Debasis; Junge, Kathrin; Beller, Matthias
Angewandte Chemie - International Edition, 2014 , vol. 53, # 6 p. 1630 - 1635
Angew. Chem., 2014 , vol. 126, # 6 p. 1656 - 1661,6
反应条件
1: phenylmethanethiol With chlorine in benzene T=0°C; 1 h; 2: phthalimide With N-ethyl-N,N-diisopropylamine in benzene T=0 - 20°C; 2 h;
参考文献
Heldreth, Bart; Long, Timothy E.; Jang, Seyoung; Reddy, G. Suresh Kumar; Turos, Edward; Dickey, Sonja; Lim, Daniel V.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 11 p. 3775 - 3784
