136918-14-4合成路线 （共 708 条）
反应条件
bis(η3-allyl-μ-chloropalladium(II)); R,R-C52H44N2O2P2 chiral ligand; sodium carbonate in dichloromethane
14 h; Ambient temperature;
参考文献
Trost, Barry M.; O'Boyle, Brendan M.; Torres, Wildeliz; Ameriks, Michael K.
Chemistry - A European Journal, 2011 , vol. 17, # 28 p. 7890 - 7903
反应条件
O,O'-((S)-1,1'-binaphthyl-2,2'-diyl)-N,N'-di-(S,S)-(1-naphthalen-1-yl)-ethyl-phosphoramidite; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; triethylamine in tetrahydrofuran
T=20°C; 18 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Gnamm, Christian; Franck, Geraldine; Miller, Nicole; Stork, Timon; Broedner, Kerstin; Helmchen, Guenter
Synthesis, 2008 , # 20 p. 3331 - 3350
反应条件
tetrabutyl-ammonium chloride; lithium carbonate; bis(η3-allyl-μ-chloropalladium(II)) in toluene
T=40°C; Substitution; 40 h; Title compound not separated from byproducts;
参考文献
Harris, Michael C. J.; Jackson, Mark; Lennon, Ian C.; Ramsden, James A.; Samuel, Helen
Tetrahedron Letters, 2000 , vol. 41, # 17 p. 3187 - 3191
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; triethylamine; (S)-(+)-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-[(1S)-1-(2-methoxy-phenyl)ethyl]amine in tetrahydrofuran
T=20°C; 24 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Gnamm, Christian; Franck, Geraldine; Miller, Nicole; Stork, Timon; Broedner, Kerstin; Helmchen, Guenter
Synthesis, 2008 , # 20 p. 3331 - 3350
反应条件
sodium carbonate; (R,R)-DACH-naphthyl Trost ligand; bis(η3-allyl-μ-chloropalladium(II)) in dichloromethane
Ambient temperature; Yields of byproduct given;
参考文献
Trost, Barry M.; Bunt, Richard C.
Angewandte Chemie, 1996 , vol. 108, # 1 p. 70 - 73
反应条件
(R)-C4-TunePhos; sodium carbonate; [(ν3-allyl)PdCl]2 in tetrahydrofuran
T=25°C; Product distribution; Further Variations:ReagentsSolventsTemperatures;
参考文献
Trost, Barry M.; Horne, Daniel B.; Woltering, Michael J.
Chemistry - A European Journal, 2006 , vol. 12, # 25 p. 6607 - 6620
反应条件
1: 73 percent / K2CO3 / dimethylformamide / 72 h
2: 85 percent / K2CO3 / acetonitrile / 24 h / Heating
3: H2 / Pd/C / toluene / 48 h / normal pressure
View Scheme
参考文献
Boehmer, Volker; Dozol, Jean-Francois; Gruettner, Cordula; Liger, Karine; Matthews, Susan E.; Rudershausen, Sandra; Saadioui, Mohamed; Wang, Pingshan
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 16 p. 2327 - 2334
反应条件
potassium carbonate in etnanol
T=20°C; 96 h;
参考文献
Gerpe, Alejandra; Bollini, Mariela; Gonzalez, Mercedes; Cerecetto, Hugo
Synthetic Communications, 2009 , vol. 39, # 1 p. 29 - 47
反应条件
1: 85 percent / CH2Cl2 / 3 h / 0 °C
2: 96 percent / triethylsilane; trifluoroboron etherate / CH2Cl2 / -15 - 20 °C
View Scheme
参考文献
Ruan, Yuan-Ping; Chen, Ming-De; He, Ming-Zhu; Zhou, Xiang; Huang, Pei-Qiang
Synthetic Communications, 2004 , vol. 34, # 5 p. 853 - 861
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; 2 h;
参考文献
FUJISAWA PHARMACEUTICAL CO. LTD.; WAKUNAGA PHARMACEUTICAL CO. LTD.
Patent: WO2004/101571 A1, 2004 ;
Location in patent: Page 30 ;
