136918-14-4合成路线 （共 708 条）
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=20°C; Mitsunobu reaction; Cooling with ice;
参考文献
Weiner, Barbara; Baeza, Alejandro; Jerphagnon, Thomas; Feringa, Ben L.
Journal of the American Chemical Society, 2009 , vol. 131, # 27 p. 9473 - 9474
反应条件
[(PPh3)3Pd] in N,N-dimethyl-formamide
T=120°C; 5 h;
参考文献
Inoue, Yoshio; Taguchi, Masaaki; Toyofuku, Masanori; Hashimoto, Harukichi
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 10 p. 3021 - 3022
反应条件
tert-butylhypochlorite; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium bromide
T=60°C; Hofmann type rearrangement; 7 h; Inert atmosphere;
参考文献
Moriyama, Katsuhiko; Ishida, Kazuma; Togo, Hideo
Chemical Communications, 2012 , vol. 48, # 68 p. 8574 - 8576
反应条件
1: methanol With iodobenzene; toluene-4-sulfonic acid; sodium sulfate; 3-chloro-benzenecarboperoxoic acid
T=0°C; 0.166667 h; Inert atmosphere;
2: phthalimide With potassium carbonate
T=0 - 20°C; Hofmann-type rearrangement; 2 h; Inert atmosphere; regioselective reaction;
参考文献
Moriyama, Katsuhiko; Ishida, Kazuma; Togo, Hideo
Organic Letters, 2012 , vol. 14, # 3 p. 946 - 949
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide
T=100°C; 12 h;
参考文献
Igel, Patrick; Geyer, Roland; Strasser, Andrea; Dove, Stefan; Seifert, Roland; Buschauer, Armin
Journal of Medicinal Chemistry, 2009 , vol. 52, # 20 p. 6297 - 6313
参考文献
Breslauer; Pictet
Chemische Berichte, 1907 , vol. 40, p. 3785
参考文献
Winstead; Heine
Journal of the American Chemical Society, 1955 , vol. 77, p. 1913
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide
T=90°C;
参考文献
Ngu, Khehyong; Weinstein, David S.; Liu, Wen; Langevine, Charles; Combs, Donald W.; Zhuang, Shaobin; Chen, Xing; Madsen, Cort S.; Harper, Timothy W.; Ahmad, Saleem; Robl, Jeffrey A.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 14 p. 4141 - 4145
反应条件
1: ethanol; H2O / Heating
2: 26 percent / benzene / 11 h / Irradiation
View Scheme
参考文献
Coyle, John D.; Newport, Graham L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 93 - 96
反应条件
1: 53 percent / 40percent Triton B / xylene; methanol / 18 h / Heating
2: 72 percent / H2 / PtO2 / ethanol / 24 h / 3102.9 Torr
3: 72 percent / NaBH4 / tetrahydrofuran; H2O / 0 - 5 °C / pH 8-10
4: 43 percent / p-toluenesulfonic acid / xylene / 1 h / Heating
View Scheme
参考文献
Scovill, John P.; Burckhalter, Joseph H.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 23 - 27
