136918-14-4合成路线 （共 708 条）
反应条件
1: With pyridine; bromine in acetonitrile T=20°C; 2 h; 2: With methanol in acetonitrile 1 h; Cooling with ice;
参考文献
Karakullukcu, Nalan Turkoz; Yakan, Hasan; Ozturk, Seyhan; Kutuk, Halil
Phosphorus, Sulfur and Silicon and the Related Elements, 2013 , vol. 188, # 11 p. 1576 - 1583
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
参考文献
Reitz; Tuman; Marchione; Jordan Jr.; Bowden; Maryanoff
Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2110 - 2116
反应条件
1.1: nitric acid; sulfuric acid / 16 h / 5 - 20 °C 2.1: potassium hydroxide / methanol; ethanol / 3 h / 20 °C 2.2: 1 h / |Reflux View Scheme
参考文献
Bian, Xiaoli; Wang, Qian; Ke, Changhu; Zhao, Guilan; Li, Yiping
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 2022 - 2026
反应条件
in neat (no solvent) N2 stream; heating (360°C, 2 h); cooling, washing (water, aq. ethanol), repptn. (from DMF with water), washing (aq. ethanol), drying (60-80°C, 1.3 hPa), chromy. (Al2O3, pyridine/ether);
参考文献
Kopranenkov, V. N.; Makarova, E. A.; Luk'yanets, E. A.
Journal of General Chemistry USSR (English Translation), 1981 , vol. 51, p. 2353 - 2356
Zhurnal Obshchei Khimii, 1981 , vol. 51, p. 2727 - 2730
参考文献
Galanin, N. E.; Shaposhnikov, G. P.
Russian Journal of Organic Chemistry, 2012 , vol. 48, # 6 p. 851 - 857,7
反应条件
potassium carbonate in isopropyl alcohol 5 h; Reflux;
参考文献
Tammana, Rajesh; Vemula, Kiran Kumar; Guruvindapalli, Ramadasu; Yanamandr, Ramesh; Gutta, Madhusudhan
Arkivoc, 2012 , vol. 2012, # 6 p. 45 - 56
反应条件
in n-heptane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene
参考文献
Pharmacia and Upjohn Company
Patent: US6362334 B1, 2002 ;
Location in patent: Example 4 ;
反应条件
potassium fluoride on basic alumina in 2-methyl tetrahydrofuran 3 h; Inert atmosphereReflux; stereospecific reaction;
参考文献
Pace, Vittorio; Hoyos, Pilar; Fernandez, Maria; Sinisterra, Jose V.; Alcantara, Andres R.
Green Chemistry, 2010 , vol. 12, # 8 p. 1380 - 1382
反应条件
bromine in pyridine; acetonitrile 2 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 53, # 42 p. 14411 - 14416
反应条件
triethylamine in N,N-dimethyl-formamide 1 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 52, # 28 p. 9367 - 9386
