136918-14-4合成路线 （共 708 条）
参考文献
Winstead; Heine
Journal of the American Chemical Society, 1955 , vol. 77, p. 1913
参考文献
Winstead; Heine
Journal of the American Chemical Society, 1955 , vol. 77, p. 1913
参考文献
Winstead; Heine
Journal of the American Chemical Society, 1955 , vol. 77, p. 1913
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=0 - 20°C; Mitsunobi protocol-adapted Gabriel synthesis;
参考文献
Kiec-Kononowicz; Wiecek; Sasse; Ligneau; Elz; Ganellin; Schwartz; Stark; Schunack
Pharmazie, 2000 , vol. 55, # 5 p. 349 - 355
反应条件
1: potassium hydroxide / methanol; ethanol / 1 h / Inert atmosphere
2: N,N-dimethyl-formamide / Inert atmosphere; Heating
View Scheme
参考文献
Wang, Xi; Ye, Yuxuan; Zhang, Songnan; Feng, Jiajie; Xu, Yan; Zhang, Yan; Wang, Jianbo
Journal of the American Chemical Society, 2011 , vol. 133, # 41 p. 16410 - 16413
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=25°C; 3 h;
参考文献
Burgess, Kevin; Ibarzo, Javier; Linthicum, D. Scott; Russell, David H.; Shin, Hunwoo; Shitangkoon, Aroonsiri; Totani, Reiko; Zhang, Alex J.
Journal of the American Chemical Society, 1997 , vol. 119, # 7 p. 1556 - 1564
反应条件
triethylamine in N,N-dimethyl-formamide
T=90 - 100°C; 1.5 h;
参考文献
Zingel, V.; Elz, S.; Schunack, W.
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 673 - 680
反应条件
1.1: sodium t-butanolate / ethanol; ethyl acetate / 40 - 50 °C
2.1: bromine / methanol / 5 h / 20 - 25 °C
2.2: 1 h / Reflux
3.1: potassium hydroxide / 1 h / Reflux
View Scheme
参考文献
Beliaev, Alexandre; Wahnon, Jorge; Russo, Domenico
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 704 - 709
反应条件
tin(IV) chloride
T=115 - 120°C;
参考文献
Errera; Gasparini
Gazzetta Chimica Italiana, 1894 , vol. 24 I, p. 75
反应条件
1: potassium carbonate; xylene / 140 °C
2: benzene
View Scheme
参考文献
Beer
Zhurnal Obshchei Khimii, 1939 , vol. 9, p. 2158,2161
Chem. Zentralbl., 1940 , vol. 111, # I p. 3112
