136918-14-4合成路线 （共 708 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Wang, You-Qing; Lu, Sheng-Mei; Zhou, Yong-Gui
Organic Letters, 2005 , vol. 7, # 15 p. 3235 - 3238
反应条件
[(PPh3)3Pd] in N,N-dimethyl-formamide
T=120°C; 5 h;
参考文献
Inoue, Yoshio; Taguchi, Masaaki; Toyofuku, Masanori; Hashimoto, Harukichi
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 10 p. 3021 - 3022
反应条件
potassium carbonate in acetone
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4390534 A1, 1983 ;
反应条件
in methanol
T=20°C; 24 h;
参考文献
Varlamov, S. V.; Kadorkina, G. K.; Kostyanovskii, R. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , p. 320 - 325
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 3 p. 390 - 395
参考文献
Moore; Rapala
Journal of the American Chemical Society, 1946 , vol. 68, p. 1657
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Hellmann et al.
Chemische Berichte, 1954 , vol. 87, p. 1690,1697
参考文献
Weaver et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 222,224
反应条件
1.1: sodium hydroxide; bromine / water / 0.03 h / -5 °C / |Reflux
1.2: pH 4 - 5
2.1: N,N-dimethyl-formamide / 0 - 20 °C
3.1: N,N-dimethyl-formamide / 24 h / 80 °C
4.1: phosphoric acid / 3 h / 130 °C
4.2: |Cooling with ice
View Scheme
参考文献
Yin, Ruijuan; Zhang, Meng; Hao, Cui; Wang, Wei; Qiu, Peiju; Wan, Shengbiao; Zhang, Lijuan; Jiang, Tao
Chemical Communications, 2013 , vol. 49, # 76 p. 8516 - 8518
反应条件
sodium metaborate; tetra-(n-butyl)ammonium iodide; potassium bromide in N,N-dimethyl-formamide
T=20°C; 10 h;
参考文献
Zav'yalov, S. I.; Ezhova, G. I.; Sitkareva, I. V.; Zavozin, A. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, p. 1739
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 8 p. 1940
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
Inert atmosphere;
参考文献
Moukha-Chafiq, Omar; Reynolds, Robert C.
ACS Combinatorial Science, 2013 , vol. 15, # 3 p. 147 - 152
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; Mitsunobu reaction; 3 h;
参考文献
Leonard, Kristi; Marugan, Juan Jose; Raboisson, Pierre; Calvo, Raul; Gushue, Joan M.; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3463 - 3468
