136918-14-4合成路线 （共 708 条）
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide
T=60°C; 72 h; Yield given;
参考文献
Bock, Mark G.; DiPardo, Robert M.; Evans, Ben E.; Rittle, Kenneth E.; Whitter, Willie L.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 450 - 455
参考文献
Stankyavichene, L. M. M.; Stankyavichyus, A. P.; Sapragonene, M. S.; Riselis, S. P.; Terent'ev, G. V.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 3 p. 217 - 221
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 3 p. 328 - 332
参考文献
Petrow; Stephenson
Journal of Pharmacy and Pharmacology, 1953 , vol. 5, p. 359,366
反应条件
1: 99 percent / triethylbenzylammonium chloride, sodium, ethanol / 5 h / Heating
2: 80 percent / 5percent H2SO4 / Heating
3: 80 percent / hydroquinone, boron trifluoride etherate, mercuric acetate / 5 h / 40 °C
View Scheme
参考文献
Komarova, L. I.; Pokrovskaya-Dukhnenko, E. M.; Zaiko, I. A.
Journal of Organic Chemistry USSR (English Translation), 1986 , vol. 22, # 11 p. 2089 - 2092
Zhurnal Organicheskoi Khimii, 1986 , vol. 22, # 11 p. 2327 - 2331
反应条件
1: NaOEt / ethanol; ethyl acetate / Heating
2: 1.) Br2, 2.) 10.0M aq. H2SO4 / 1.) MeOH, from 0 deg C to RT, 2.) RT
3: 99 percent / acetone / Ambient temperature
View Scheme
参考文献
Eriks; Van der Goot; Sterk; Timmerman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3239 - 3246
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=120°C;
参考文献
Caldirola, PM; Goot, H van der; Timmerman, H
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 571 - 579
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Wang, You-Qing; Lu, Sheng-Mei; Zhou, Yong-Gui
Organic Letters, 2005 , vol. 7, # 15 p. 3235 - 3238
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Wang, You-Qing; Lu, Sheng-Mei; Zhou, Yong-Gui
Organic Letters, 2005 , vol. 7, # 15 p. 3235 - 3238
反应条件
in 1,4-dioxane
2 h; Ambient temperature;
参考文献
Okachi, Ryo; Niino, Hideki; Kitaura, Kozo; Mineura, Kazuyuki; Nakamizo, Yoshinobu; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1772 - 1779
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Kowalski, Piotr; Mitka, Katarzyna; Jaskowska, Jolanta; Duszynska, Beata; Bojarski, Andrzej J.
Archiv der Pharmazie, 2013 , vol. 346, # 5 p. 339 - 348
