136918-14-4合成路线 （共 708 条）
反应条件
potassium hydroxide; 1-butylpyridinium tetrafluoroborate T=40°C; 5 h;
参考文献
Le, Zhang-Gao; Chen, Zhen-Chu; Hu, Yi; Zheng, Qin-Guo
Synthesis, 2004 , # 2 p. 208 - 212
反应条件
PhP(C6H4-p-(CH2)2C6F13)2; diethylazodicarboxylate in tetrahydrofuran
参考文献
Dandapani, Sivaraman; Curran, Dennis P.
Tetrahedron, 2002 , vol. 58, # 20 p. 3855 - 3864
参考文献
Kantlehner, Willi; Maier, Thomas; Loeffler, Wolfgang; Kapassakalidis, Joanis J.
Liebigs Annalen der Chemie, 1982 , # 3 p. 507 - 529
反应条件
sodium ethanolate in ethanol; ethyl acetate 1.) RT, 2 h, 2.) reflux, 2 h;
参考文献
Rasapalli, Sivappa; Kumbam, Venkatreddy; Dhawane, Abasaheb N.; Golen, James A.; Lovely, Carl J.; Rheingold, Arnold L.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 25 p. 4133 - 4137
反应条件
in methanol; ethyl acetate
参考文献
Pfizer Inc.
Patent: US5037834 A1, 1991 ;
反应条件
in N,N-dimethyl-formamide 5 h; Reflux;
参考文献
SYMED LABS LIMITED; MOHAN RAO, dodda; KRISHNA REDDY, pingili; ANNA REDDY, ambati; VENKAT REDDY, buthukuri
Patent: WO2012/32533 A2, 2012 ;
Location in patent: Page/Page column 16 ;
反应条件
1.1: sodium carbonate; N-benzyl-N,N,N-triethylammonium chloride / isopropyl alcohol / 20 - 40 °C 1.2: 5 - 10 °C 2.1: water; methanol / 20 h / Reflux View Scheme
参考文献
FARMAK, A.S.; URBASEK, Miroslav; HRADIL, Pavel; GREPL, Martin; FIALOVA, Petra; OREMUS, Vladimir; SLEZAR, Petr
Patent: WO2012/41263 A2, 2012 ;
反应条件
N-methyl-pyrrolidine; sulfuric acid; lithium bromide; [PdBr2(PPh3)2] T=120°C; P=45003.6 Torr; 12 h;
参考文献
Enzmann, Armin; Eckert, Markus; Ponikwar, Walter; Polborn, Kurt; Schneiderbauer, Stefan; Beller, Matthias; Beck, Wolfgang
European Journal of Inorganic Chemistry, 2004 , # 6 p. 1330 - 1340
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu reaction;
参考文献
Bhatti, Balwinder S.; Strachan, Jon-Paul; Breining, Scott R.; Miller, Craig H.; Tahiri, Persida; Crooks, Peter A.; Deo, Niranjan; Day, Cynthia S.; Caldwell, William S.
Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3497 - 3507
反应条件
potassium carbonate in ethanol 22 h; Heating;
参考文献
Ahmed; Stratford; Jenkins
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 12 p. 1763 - 1768
