反应条件
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane; water / 100 °C / Inert atmosphere
2: toluene-4-sulfonic acid / methanol / 20 °C
3: triethylamine; methanesulfonyl chloride / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 - 20 °C
4: trichlorophosphate / 1 h / 130 °C
View Scheme
参考文献
GLAXO GROUP LIMITED; WAN, Zehong; ZHANG, Xiaomin; TONG, Zhaolong; LONG, Kai; DOWDELL, Sarah E.; MANAS, Eric Steven; GOODMAN, Krista Beaver
Patent: WO2012/37782 A1, 2012 ;
WO 2012/037782 A1
