1: cyclopentyl-bromide With iodine; magnesium in diethyl ether 1 h; 2: ortho-chloro-benzonitrile With copper(I) bromide in diethyl ether 16 h; 3: With water
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potassium carbonate in N,N-dimethyl-formamide T=65°C; 16 h;
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Journal of Medicinal Chemistry, 1995 , vol. 38, # 24 p. 4848 - 4854