利多卡因合成路线

参考文献

Nouri-Nigjeh, Eslam; Permentier, Hjalmar P.; Bischoff, Rainer; Bruins, Andries P.
Analytical Chemistry, 2011 , vol. 83, # 14 p. 5519 - 5525

137-58-6利多卡因

18865-38-82-氨基-N-(2,6-二甲基苯基)乙酰胺+

7728-40-7去乙基利多卡因

参考文献

Poraj-Kobielska, Marzena; Kinne, Matthias; Ullrich, Rene; Scheibner, Katrin; Kayser, Gernot; Hammel, Kenneth E.; Hofrichter, Martin
Biochemical Pharmacology, 2011 , vol. 82, # 7 p. 789 - 796

137-58-6利多卡因

34604-55-23-羟基利多卡因+

18865-38-82-氨基-N-(2,6-二甲基苯基)乙酰胺+

7728-40-7去乙基利多卡因+

34604-56-32-乙基氨基-N-(3-羟基-2,6-二甲基苯基)乙酰胺

参考文献

Kawai; Fujita; Suzuki
Journal of Pharmaceutical Sciences, 1985 , vol. 74, # 11 p. 1219 - 1224

参考文献

Nouri-Nigjeh, Eslam; Permentier, Hjalmar P.; Bischoff, Rainer; Bruins, Andries P.
Analytical Chemistry, 2011 , vol. 83, # 14 p. 5519 - 5525

137-58-6利多卡因

7728-40-7去乙基利多卡因

参考文献

Poraj-Kobielska, Marzena; Kinne, Matthias; Ullrich, Rene; Scheibner, Katrin; Kayser, Gernot; Hammel, Kenneth E.; Hofrichter, Martin
Biochemical Pharmacology, 2011 , vol. 82, # 7 p. 789 - 796

137-58-6利多卡因

18865-38-82-氨基-N-(2,6-二甲基苯基)乙酰胺+

7728-40-7去乙基利多卡因

参考文献

Poraj-Kobielska, Marzena; Kinne, Matthias; Ullrich, Rene; Scheibner, Katrin; Kayser, Gernot; Hammel, Kenneth E.; Hofrichter, Martin
Biochemical Pharmacology, 2011 , vol. 82, # 7 p. 789 - 796

137-58-6利多卡因

34604-55-23-羟基利多卡因+

18865-38-82-氨基-N-(2,6-二甲基苯基)乙酰胺+

7728-40-7去乙基利多卡因+

34604-56-32-乙基氨基-N-(3-羟基-2,6-二甲基苯基)乙酰胺

参考文献

Kawai; Fujita; Suzuki
Journal of Pharmaceutical Sciences, 1985 , vol. 74, # 11 p. 1219 - 1224

137-58-6利多卡因

1044658-01-6N-(3-溴-2,6-二甲基苯基)-2-(二乙基氨基)乙酰胺

参考文献

CORUS PHARMA
Patent: WO2005/25498 A2, 2005 ;
Location in patent: Page/Page column 50 ;

137-58-6利多卡因

34604-55-23-羟基利多卡因+

18865-38-82-氨基-N-(2,6-二甲基苯基)乙酰胺+

7728-40-7去乙基利多卡因+

34604-56-32-乙基氨基-N-(3-羟基-2,6-二甲基苯基)乙酰胺

参考文献

Kawai; Fujita; Suzuki
Journal of Pharmaceutical Sciences, 1985 , vol. 74, # 11 p. 1219 - 1224

137-58-6利多卡因+

100-44-7苄基氯

1674-99-3氯化地那铵

参考文献

DISHMAN PHARMACEUTICALS AND CHEMICALS LTD.; PLUIM, Henk
Patent: WO2006/62406 A2, 2006 ;
Location in patent: Page/Page column 6 ;