4-(1H-吡咯-1-甲基)苯甲酸合成路线 （共 5 条）
反应条件
acetic acid
T=150°C; Paal-Knorr pyrrole synthesis; 0.166667 h; Microwave irradiation;
参考文献
Liu, Kun; Lu, Hong; Hou, Ling; Qi, Zhi; Teixeira, Catia; Barbault, Florent; Fan, Bo-Tao; Liu, Shuwen; Jiang, Shibo; Xie, Lan
Journal of Medicinal Chemistry, 2008 , vol. 51, # 24 p. 7843 - 7854
反应条件
potassium hydroxide in ethanol
3 h; Heating;
参考文献
Silvestri; Pagnozzi; Valoti; Fusi
Farmaco, 1994 , vol. 49, # 10 p. 625 - 632
反应条件
1: 71 percent / Na2CO3 / CHCl3 / 4 h / Heating
2: aq. HCl / 48 h / Heating
View Scheme
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
hydrogenchloride
48 h; Heating;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
sodium hydride
1.) 2 h, 2.) overnight; Yield given. Multistep reaction;
参考文献
Striley, Cynthia A. F.; Amer, Adel; Zhang, Wei Yuan; Zimmer, Hans; Lando, Jerome B.
Phosphorus, Sulfur and Silicon and Related Elements, 1996 , vol. 115, p. 141 - 148
