CHIRALPAK.(R). AD-H column in ethanol; n-heptane Resolution of racemate;

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C 1.2: -78 - 20 °C 2.1: CHIRALPAK AD-H column / n-heptane; ethanol / Resolution of racemate View Scheme

1.1: triethylamine / dichloromethane / 4 h / 20 °C / Cooling with ice 2.1: caesium carbonate / acetonitrile / 60 °C / Inert atmosphere 3.1: acetyl chloride; methanol / 4 h / 20 °C / Inert atmosphere; Cooling with ice 3.2: 0.5 h / 20 °C View Scheme