1: methanesulfonic acid / tetrahydrofuran / 0 °C 2: hydrogen; ammonia / palladium 10 on activated carbon / water; tetrahydrofuran; methanol / 6 h / 20 °C 3: triethylamine / acetonitrile / 0 - 20 °C / Inert atmosphere 4: triethylamine / dichloromethane / 0 °C / Inert atmosphere 5: acetic anhydride / 5 h / 75 - 80 °C / Inert atmosphere 6: hydrogenchloride; water / methanol / 1.5 h / 20 °C 7: sodium hydroxide; water / methanol / 0 - 20 °C / pH 12 View Scheme

1: methanesulfonic acid / tetrahydrofuran / 0 °C 2: hydrogen; ammonia / palladium 10 on activated carbon / water; tetrahydrofuran; methanol / 6 h / 20 °C 3: triethylamine / acetonitrile / 0 - 20 °C / Inert atmosphere 4: triethylamine / dichloromethane / 0 °C / Inert atmosphere 5: acetic anhydride / 5 h / 75 - 80 °C / Inert atmosphere 6: hydrogenchloride; water / methanol / 1.5 h / 20 °C View Scheme