1: potassium carbonate / ethylene glycol dimethyl ether; ethanol / 2 h / Reflux 2: palladium 10 on activated carbon; hydrogen / methanol / 24 h / 20 °C / 3750.38 Torr View Scheme

potassium tert-butylate in tert-butyl alcohol T=50°C; tandem Knoevenagel-Michael addition; 4 h;

tri(isobutyl)phosphine in toluene T=120°C; 5 h; Inert atmosphere;

chloro-trimethyl-silane; copper(II) bis(trifluoromethanesulfonate); (4S,4S')-(-)-2,2'-(1-methylethylidene)bis[4,5-dihydro-4-(phenylmethyl)oxazole] in dichloromethane T=20°C; Friedel-Crafts alkylation; 0.5 h;

copper(II) bis(trifluoromethanesulfonate); (4S,4S')-(-)-2,2'-(1-methylethylidene)bis[4,5-dihydro-4-(phenylmethyl)oxazole] in dichloromethane T=20°C; Friedel-Crafts alkylation; 72 h; Title compound not separated from byproducts;

bis[(S)-4-benzyloxazoline-2-yl]-2-(furyl)-ethene; copper(II) bis(trifluoromethanesulfonate) in dichloromethane T=20°C; asymmetric Friedel Crafts amidoalkylation; 24 h; Molecular sieveInert atmosphere; optical yield given as percent eeenantioselective reaction;

FeCl3·6H2O in dichloromethane T=0 - 20°C; Friedel Crafts arylation; 3.5 h; Inert atmosphere;