1-Boc-哌啶-4-甲醛合成路线 （共 68 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-10°C; 0.166667 - 0.333333 h; 2: With hydrogenchloride; potassium hydrogensulfate in tetrahydrofuran; water 0.25 h;
参考文献
Myriad Pharmaceuticals, Inc.
Patent: US2004/14763 A1, 2004 ;
Location in patent: Page 21 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-50 - 0°C; 4 h; 2: With water; citric acid in tetrahydrofuran T=-78°C;
参考文献
4SC AG
Patent: US2007/219190 A1, 2007 ;
Location in patent: Page/Page column 18 ;
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane Swern oxidation;
参考文献
Muehlhausen, Ute; Ermert, Johannes; Herth, Matthias M.; Coenen, Heinz H.
Journal of Labelled Compounds and Radiopharmaceuticals, 2009 , vol. 52, # 1 p. 6 - 12
反应条件
1: With diisobutylaluminium hydride in diethyl ether; toluene T=-70°C; 1.33333 h; 2: With (NH4)2CO3 in water; acetone
参考文献
WO2008/31227 A1, ;
Page/Page column 21-22 ;
反应条件
sodium hydroxide; triethylamine in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; dimethyl sulfoxide; ethyl acetate
反应条件
tetrapropylammonium perruthennate; 4A molecular sieves in dichloromethane T=20°C; 1 h;
参考文献
US2004/87573 A1, ;
Page 22 ;
US 20040087573 A1
反应条件
n-butyllithium; diisobutylaluminium hydride; tert-butyl alcohol in tetrahydrofuran; hexane T=0°C;
参考文献
De Munoz, Juan M.; Alcazar, Jesus; De La Hoz, Antonio; Diaz-Ortiz, Angel
European Journal of Organic Chemistry, 2012 , # 2 p. 260 - 263
反应条件
aq. NaOH in dichloromethane
参考文献
US6399619 B1, ;
US 6399619 B1
反应条件
sodium hydroxide in dichloromethane
参考文献
US6265434 B1, ;
US 6265434 B1
反应条件
diisopropylamine in tetrahydrofuran; hexane; ethyl acetate
参考文献
US6265434 B1, ;
US 6265434 B1
