1-Boc-哌啶-4-甲醛合成路线 （共 68 条）
反应条件
1: 92 percent / aq. NaOH, Et3N / dioxane / 20 h / Ambient temperature 2: BH3*THF / tetrahydrofuran / 1 h / 0 °C 3: 69 percent / PCC, NaOAc, 3 A molecular sieves / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 13 p. 2409 - 2421
反应条件
1: BH3*THF / tetrahydrofuran / 1 h / 0 °C 2: 69 percent / PCC, NaOAc, 3 A molecular sieves / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 13 p. 2409 - 2421
反应条件
1: CH2Cl2 2: DMSO; (COCl)2; Et3N / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 22 p. 5752 - 5756
反应条件
1: 92 percent / aq. NaOH, Et3N / dioxane / 20 h / Ambient temperature 2: BH3*THF / tetrahydrofuran / 1 h / 0 °C 3: 69 percent / PCC, NaOAc, 3 A molecular sieves / CH2Cl2 / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 13 p. 2409 - 2421
反应条件
sodium hydroxide in water; acetonitrile T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 12 p. 3236 - 3240
Angew. Chem., , vol. 126, # 12 p. 3300 - 3304,5
反应条件
1: lithium hexamethyldisilazane / tetrahydrofuran / -10 °C 2: Acidic conditions; Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 5 p. 1903 - 1907
反应条件
1: DIBAL / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 13 p. 2843 - 2845
反应条件
Acidic conditionsHeating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 5 p. 1903 - 1907
反应条件
trifluoroacetic acid T=20°C;
参考文献
Iyobe; Uchida; Kamata; Hotel; Kusama; Harada
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 7 p. 822 - 829
反应条件
hydroxylamine hydrochloride; 1-propanephosphonic acid cyclic anhydride; triethylamine in ethyl acetate; N,N-dimethyl-formamide T=100°C;
参考文献
Augustine, John Kallikat; Atta, Rajendra Nath; Ramappa, Balakrishna Kolathur; Boodappa, Chandrakantha
Synlett, 2009 , # 20 p. 3378 - 3382
