1-Boc-哌啶-4-甲醛合成路线 （共 68 条）
反应条件
triethylamine in toluene
14 h; Heating / reflux;
参考文献
4 SC AG
Patent: US2006/69102 A1, 2006 ;
Location in patent: Page/Page column 17 ;
反应条件
triethylamine in toluene
14 h; Heating / reflux;
参考文献
4SC AG
Patent: US2007/219190 A1, 2007 ;
Location in patent: Page/Page column 18 ;
反应条件
in tetrahydrofuran; toluene
T=20°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/113837 A2, 2006 ;
Location in patent: Page/Page column 131 ;
WO 2006/113837 A2
反应条件
1: potassium carbonate / diethyl ether / 6 h / 20 °C / Inert atmosphere
2: hydrogenchloride; water / 2 h / Inert atmosphere
View Scheme
参考文献
Choi, Junwon; Fu, Gregory C.
Journal of the American Chemical Society, 2012 , vol. 134, # 22 p. 9102 - 9105
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexanes
T=-78°C; 0.5 h;
2: acetonitrile in tetrahydrofuran; hexanes
0.5 h;
3: 4-formyl-piperidine-1-carboxylic acid tert-butyl ester in tetrahydrofuran; hexanes
2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/113837 A2, 2006 ;
Location in patent: Page/Page column 132-133 ;
WO 2006/113837 A2
反应条件
sodium hydride in dimethyl sulfoxide
T=20°C;
参考文献
Someya, Hidenori; Kondoh, Azusa; Sato, Akinori; Ohmiya, Hirohisa; Yorimitsu, Hideki; Oshima, Koichiro
Synlett, 2006 , # 18 p. 3061 - 3064
反应条件
sodium tris(acetoxy)borohydride in dichloromethane
18 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/103000 A1, 2005 ;
Location in patent: Page/Page column 37-38 ;
WO 2005/103000 A1
反应条件
1: acetic acid / 1,2-dichloro-ethane / 48 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 20 °C
View Scheme
参考文献
Bogatcheva, Elena; Hanrahan, Colleen; Nikonenko, Boris; De Los Santos, Gladys; Reddy, Venkata; Chen, Ping; Barbosa, Francis; Einck, Leo; Nacy, Carol; Protopopova, Marina
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5353 - 5357
