1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸三叔丁酯合成路线 （共 19 条）
反应条件
Pd on carbon in ethanol
参考文献
Carpenter, JR., Alan P.
Patent: US2002/106325 A1, 2002 ;
Title/Abstract Full Text Show Details
Bristol-Myers Squibb Pharma Company
Patent: US6537520 B1, 2003 ;
反应条件
sodium hydroxide in methanol; water T=20°C; 24 h;
参考文献
Laakso, Johanna; Rosser, Geraldine A.; Szijjarto, Csongor; Beeby, Andrew; Borbas, K. Eszter
Inorganic Chemistry, 2012 , vol. 51, # 19 p. 10366 - 10374
反应条件
potassium carbonate in methanol; water T=40°C; pH=11; 48 h;
参考文献
WO2006/36071 A2, ;
Page/Page column 23 ;
WO 2006/036071 A2
反应条件
1: 99 percent / potassium carbonate / acetonitrile / 12 h / 70 °C 2: 95 percent / aq.NaOH / dioxane / 4 h / 50 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 47 p. 15072 - 15073
反应条件
1: 100 percent / K2CO3 / acetonitrile / 2.5 h / 20 °C 2: H2 / 10 percent Pd/C / tetrahydrofuran; methanol / 5 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 5, # 7 p. 1974 - 1981
反应条件
water; sodium hydroxide in methanol
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 11 p. 3346 - 3348
反应条件
4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0) in dichloromethane T=20°C; 2 h;
参考文献
Jamous, Mazen; Haberkorn, Uwe; Mier, Walter
Tetrahedron Letters, 2012 , vol. 53, # 50 p. 6810 - 6814
反应条件
1: 1,4,7,10-tetraazacyclododecane-4,7,10-tris(acetic acid tert-butyl ester) With potassium carbonate in N,N-dimethyl-formamide T=80°C; 0.5 h; 2: monobromoacetic acid in N,N-dimethyl-formamide T=70°C; 2 h; Further stages.;
参考文献
Kohl, Stephan W.; Kuse, Katharina; Hummert, Markus; Schumann, Herbert; Muegge, Clemens; Janek, Katharina; Weisshoff, Hardy
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007 , vol. 62, # 3 p. 397 - 406
反应条件
1: triethylamine / chloroform / 20 °C / Inert atmosphere 2: potassium carbonate / acetonitrile / 3 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol / 12 h / 20 °C View Scheme
参考文献
Chemical Communications, , vol. 47, # 31 p. 8835 - 8837
反应条件
1: 100 percent / K2CO3 / acetonitrile / 2.5 h / 20 °C 2: H2 / 10 percent Pd/C / tetrahydrofuran; methanol / 5 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 5, # 7 p. 1974 - 1981
